DOPPLER ANALYSIS OF UTERINE BLOOD-FLOW CHANGES IN SPONTANEOUS AND MEDICALLY INDUCED MENOPAUSE

被引：12

作者：

BATTAGLIA, C

ARTINI, PG

BENCINI, S

BIANCHI, R

DAMBROGIO, G

GENAZZANI, AR

机构：

[1] Department of Obstetrics and Gynecology, School of Medicine, University of Modena, Modena

来源：

GYNECOLOGICAL ENDOCRINOLOGY | 1995年 / 9卷 / 02期

关键词：

DOPPLER; POSTMENOPAUSE; GNRH ANALOGS; ULTRASOUND; HYPOESTROGENISM;

D O I：

10.3109/09513599509160204

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of this study was to compare the uterine blood flow variations induced by chemical castration and spontaneous menopause. Thirty infertile patients were studied in the early follicular phase (day 5-7) and then treated with gonadotropin releasing hormone agonists (GnRH-a). On day 25 from GnRH-a injection, the suppressive effect was checked. The values obtained were compared with those found in 18 postmenopausal women (menopause < 5 years). All the subjects underwent transvaginal ultrasonography, Doppler analysis of uterine arteries, hormonal assay and evaluation of hematological and biochemical parameters. In all infertile patients, the GnRH-a suppressive effect was shown at the 25th day from the injection. Endometrium thickness decreased from 0.6 +/- 0.1 mm to 0.3 +/- 0.1 mm (p < 0.05) and the pulsatility index increased from 2.52 +/- 0.31 to 3.02 +/- 0.25 (p < 0.05). The plasma estradiol level fell from 48.2 +/- 4.4 pg/ml to 13.6 +/- 7.9 pg/ml (p < 0.05). No other hormonal and biochemical parameters were significantly modified by GnRH-a. In postmenopausal women, the values of the studied parameters were similar to those found in the infertile GnRH-a-suppressed patients. These data show that GnRH-a induces vascular modifications similar to those induced by early post-menopause and that both are probably exclusively related to hypoestrogenism.

引用

页码：143 / 148

页数：6

共 25 条

[1]

Jaffe R.B., The menopause and perimenopausal period, Reproductive Endocrinology, pp. 389-408, (1991)

[2]

London S.N., Hammond C.B., The climacteric, Danforth's Obstetrics and Gynecology, pp. 853-873, (1990)

[3]

Zalud I., Conway C., Schulman H., Trinca D., Endometrial and myometrial thickness and uterine blood flow in postmenopausal women: the influence of hormonal replacement therapy and age, J. Ultrasound Med, 12, pp. 737-741, (1993)

[4]

Buhler K., Winkler U., Schindler A.E., Influence on hormone levels, lipid metabolism and reversibility of endocrinological changes after leuprolin acetate depot therapy, Clin. Ther, 14, pp. 104-113, (1992)

[5]

Matta W.H.M., Stabile I., Shaw R., Campbell S., Doppler assessment of uterine blood flow changes in patients with fibroids receiving the gonadotropin-releasing hormone agonist buserelin, Fertil. Steril, 49, pp. 1083-1085, (1988)

[6]

Adamson G.D., Treatment of uterine fibroids: current findings with gonadotropin-releasing hormone agonists, Am. J. Obstet. Gynecol, 166, pp. 746-751, (1992)

[7]

Judd H.L., Gonadotropin-releasing hormone agonists: strategies for managing the hypoestrogenic effects of therapy, Am. J. Obstet. Gynecol, 166, pp. 752-756, (1992)

[8]

Lemay A., Surrey E.S., Friedman A.J., Extending the use of gonadotropin-releasing hormone agonists: the emerging role of steroidal and nonsteroidal agents, Fertil. Steril, 61, pp. 21-34, (1994)

[9]

Clayton R.N., Mechanism of GnRH action in gonadotrophs, Hum. Reprod, 3, pp. 479-483, (1988)

[10]

Steer C.V., Campbell S., Pampiglione J., Kingsland C., Mason B.A., Collins W.P., Transvaginal color flow imaging of uterine arteries during the ovarian and menstrual cycle, Hum. Reprod, 5, pp. 391-395, (1990)

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