PREPARATION OF LYOPHILIZED HEAT-TREATED CRYOPRECIPITATES FROM A SMALL POOL OF PLASMA OBTAINED BY APHERESIS

被引：5

作者：

ALLERSMA, DP

ROEFFEN, E

VANDERDOES, JA

BRIET, E

机构：

[1] RED CROSS BLOOD BANK,2545 CJ THE HAGUE,NETHERLANDS

[2] UNIV HOSP LEIDEN,DEPT HAEMATOL,2300 RA LEIDEN,NETHERLANDS

来源：

PHARMACEUTISCH WEEKBLAD-SCIENTIFIC EDITION | 1991年 / 13卷 / 01期

关键词：

BLOOD BANKS; DRUG COMPOUNDING; FACTOR-VIII; FREEZE DRYING; PLASMA;

D O I：

10.1007/BF01963879

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A method was developed for the batch-wise production of small-pool lyophilized heat-treated cryoprecipitates in a regional Blood Bank. Ten vials of final product were derived from twenty 600 g apheresis plasma donations. We found 384 IU of factor VIII per vial and a specific activity of 0.20 IU per mg total protein. Production recovery was 340 IU of factor VIII per kg plasma. The method was easy to perform and gave a product of good quality.

引用

页码：18 / 23

页数：6

共 20 条

[1] QUALITY-CONTROL PROGRAM FOR THE PREPARATION OF SMALL-POOL LYOPHILIZED HEAT-TREATED CRYOPRECIPITATES [J].