CLONING, EXPRESSION AND TISSUE DISTRIBUTION OF THE GENE ENCODING RAT FIBROBLAST GROWTH-FACTOR RECEPTOR SUBTYPE-4

被引：31

作者：

HORLICK, RA

STACK, SL

COOKE, GM

机构：

[1] The Du Pont Merck Pharmaceutical Co., Wilmington, DE 19880-0400, P.O. Box 80400, Experimental Station

来源：

GENE | 1992年 / 120卷 / 02期

关键词：

INTRACELLULAR RECEPTOR; LUNG CDNA; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; PROTEIN-TYROSINE KINASE;

D O I：

10.1016/0378-1119(92)90108-2

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The rat homologue of the gene encoding the fibroblast growth factor receptor subtype 4 (FGFR4) was cloned from rat lung mRNA, and the cDNA sequence was found to be 95% similar and 92% identical to the human homologue. Northern blot analysis of adult rat tissues demonstrated that a 3.1-kb mRNA encoding FGFR4 is detectable only in the lung and kidney. The receptor variant described here encodes two potential immunoglobulin-like domains, 21 hydrophobic amino acids encoding a potential transmembrane domain, and a split tyrosine kinase motif. However, the acidic box and hydrophobic signal peptide domains are not present in this cDNA isolate.

引用

收藏

页码：291 / 295

页数：5

相关论文

共 21 条

[1] A COMPREHENSIVE SET OF SEQUENCE-ANALYSIS PROGRAMS FOR THE VAX [J].

DEVEREUX, J ;

HAEBERLI, P ;

SMITHIES, O .

NUCLEIC ACIDS RESEARCH, 1984, 12 (01) :387-395

[2] CLONING AND EXPRESSION OF 2 DISTINCT HIGH-AFFINITY RECEPTORS CROSS-REACTING WITH ACIDIC AND BASIC FIBROBLAST GROWTH-FACTORS [J].

DIONNE, CA ;

CRUMLEY, G ;

BELLOT, F ;

KAPLOW, JM ;

SEARFOSS, G ;

RUTA, M ;

BURGESS, WH ;

JAYE, M ;

SCHLESSINGER, J .

EMBO JOURNAL, 1990, 9 (09) :2685-2692

[3] RAPID PRODUCTION OF FULL-LENGTH CDNAS FROM RARE TRANSCRIPTS - AMPLIFICATION USING A SINGLE GENE-SPECIFIC OLIGONUCLEOTIDE PRIMER [J].

FROHMAN, MA ;

DUSH, MK ;

MARTIN, GR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (23) :8998-9002

[4]

GOLDFARB M, 1990, CELL GROWTH DIFFER, V1, P439

[5] SITE-DIRECTED MUTAGENESIS BY OVERLAP EXTENSION USING THE POLYMERASE CHAIN-REACTION [J].

HO, SN ;

HUNT, HD ;

HORTON, RM ;

PULLEN, JK ;

PEASE, LR .

GENE, 1989, 77 (01) :51-59

[6] ENGINEERING HYBRID GENES WITHOUT THE USE OF RESTRICTION ENZYMES - GENE-SPLICING BY OVERLAP EXTENSION [J].

HORTON, RM ;

HUNT, HD ;

HO, SN ;

PULLEN, JK ;

PEASE, LR .

GENE, 1989, 77 (01) :61-68

[7] FIBROBLAST GROWTH-FACTOR RECEPTORS FROM LIVER VARY IN 3 STRUCTURAL DOMAINS [J].

HOU, JZ ;

KAN, M ;

MCKEEHAN, K ;

MCBRIDE, G ;

ADAMS, P ;

MCKEEHAN, WL .

SCIENCE, 1991, 251 (4994) :665-668

[8] RELATED FIBROBLAST GROWTH-FACTOR RECEPTOR GENES EXIST IN THE HUMAN GENOME [J].

HOUSSAINT, E ;

BLANQUET, PR ;

CHAMPIONARNAUD, P ;

GESNEL, MC ;

TORRIGLIA, A ;

COURTOIS, Y ;

BREATHNACH, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (20) :8180-8184

[9] COMPLETE SEQUENCE OF A HUMAN RECEPTOR FOR ACIDIC AND BASIC FIBROBLAST GROWTH-FACTORS [J].

ISACCHI, A ;

BERGONZONI, L ;

SARMIENTOS, P .

NUCLEIC ACIDS RESEARCH, 1990, 18 (07) :1906-1906

[10] DIVERSE FORMS OF A RECEPTOR FOR ACIDIC AND BASIC FIBROBLAST GROWTH-FACTORS [J].

JOHNSON, DE ;

LEE, PL ;

LU, J ;

WILLIAMS, LT .

MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (09) :4728-4736