T-CELL RECEPTOR V-GENE USAGE IN SYNOVIAL-FLUID AND SYNOVIAL TISSUE FROM RA PATIENTS

被引:21
作者
GUDMUNDSSON, S
RONNELID, J
KARLSSONPARRA, A
LYSHOLM, J
GUDBJORNSSON, B
WIDENFALK, B
JANSON, CH
KLARESKOG, L
机构
[1] FALUN CENT HOSP,DEPT RHEUMATOL,FALUN,SWEDEN
[2] KAROLINSKA INST,DEPT IMMUNOL,S-10401 STOCKHOLM 60,SWEDEN
[3] UNIV HOSP UPPSALA,DEPT HAND SURG,S-75185 UPPSALA,SWEDEN
[4] UNIV HOSP UPPSALA,DEPT RHEUMATOL,S-75185 UPPSALA,SWEDEN
关键词
D O I
10.1111/j.1365-3083.1992.tb03128.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The question of whether there is a preferential use of certain V genes in T cells entering an inflamed joint has hitherto been studied mainly using unfractionated cells from synovial fluid and tissue respectively, and no clear answer to the question has yet been provided. Concomitantly, evidence has been provided that the use of V genes may differ considerably between CD4+ and CD8+ T cells, and consequently that detection of biased V-gene expression within an inflammatory lesion may require separate analysis of the two T-cell subsets. In this paper we have therefore studied T-cell receptor V-gene expression in rheumatoid arthritis by means of double stainings of synovial fluid and blood for available anti-TCR monoclonal antibodies and antibodies to CD4 and CD8, respectively. Double stainings were also performed with anti-TCR antibodies and antibodies to activation markers HLA-DR and IL-2R. A certain bias towards the preferential use of certain V genes was seen particularly in the synovial fluid samples within both the CD4+ and CD8+ T-cell populations, but no uniform pattern was evident among the 35 patients investigated.
引用
收藏
页码:681 / 688
页数:8
相关论文
共 26 条
[1]   LIMITED HETEROGENEITY OF T-CELL RECEPTORS FROM LYMPHOCYTES MEDIATING AUTOIMMUNE ENCEPHALOMYELITIS ALLOWS SPECIFIC IMMUNE INTERVENTION [J].
ACHAORBEA, H ;
MITCHELL, DJ ;
TIMMERMANN, L ;
WRAITH, DC ;
TAUSCH, GS ;
WALDOR, MK ;
ZAMVIL, SS ;
MCDEVITT, HO ;
STEINMAN, L .
CELL, 1988, 54 (02) :263-273
[2]   IDIOTYPE-LIKE MOLECULES ON CELLS OF A HUMAN T-CELL LEUKEMIA [J].
BIGLER, RD ;
FISHER, DE ;
WANG, CY ;
KAN, EAR ;
KUNKEL, HG .
JOURNAL OF EXPERIMENTAL MEDICINE, 1983, 158 (03) :1000-1005
[3]   T-CELL SPECIFICITY AND REPERTOIRE [J].
BLACKMAN, MA ;
KAPPLER, JW ;
MARRACK, P .
IMMUNOLOGICAL REVIEWS, 1988, 101 :5-19
[4]  
BOYLSTON AW, 1986, J IMMUNOL, V137, P741
[5]  
BRENNAN FM, 1988, CLIN EXP IMMUNOL, V73, P417
[6]   CHARACTERIZATION OF T-CELL RECEPTOR-ALPHA-BETA REPERTOIRE IN SYNOVIAL TISSUE FROM DIFFERENT TEMPORAL PHASES OF RHEUMATOID-ARTHRITIS [J].
BUCHT, A ;
OKSENBERG, JR ;
LINDBLAD, S ;
GRONBERG, A ;
STEINMAN, L ;
KLARESKOG, L .
SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1992, 35 (02) :159-165
[7]   CLONAL HETEROGENEITY OF SYNOVIAL-FLUID LYMPHOCYTES-T FROM PATIENTS WITH RHEUMATOID-ARTHRITIS [J].
DUBY, AD ;
SINCLAIR, AK ;
OSBORNELAWRENCE, SL ;
ZELDES, W ;
KAN, L ;
FOX, DA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (16) :6206-6210
[8]   THE SHARED EPITOPE HYPOTHESIS - AN APPROACH TO UNDERSTANDING THE MOLECULAR-GENETICS OF SUSCEPTIBILITY TO RHEUMATOID-ARTHRITIS [J].
GREGERSEN, PK ;
SILVER, J ;
WINCHESTER, RJ .
ARTHRITIS AND RHEUMATISM, 1987, 30 (11) :1205-1213
[9]   RESTRICTED V-ALPHA-2.3 GENE USAGE BY CD4+ LYMPHOCYTES-T IN BRONCHOALVEOLAR LAVAGE FLUID FROM SARCOIDOSIS PATIENTS CORRELATES WITH HLA-DR3 [J].
GRUNEWALD, J ;
JANSON, CH ;
EKLUND, A ;
OHRN, M ;
OLERUP, O ;
PERSSON, U ;
WIGZELL, H .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1992, 22 (01) :129-135
[10]  
HARRIS ED, 1989, TXB RHEUMATOLOGY, P886