THE EXOGENOUS ORIGIN OF TRIMETHYLAMINE IN THE MOUSE

被引：158

作者：

ALWAIZ, M ^{[1
]}

MIKOV, M ^{[1
]}

MITCHELL, SC ^{[1
]}

SMITH, RL ^{[1
]}

机构：

[1] ST MARYS HOSP,SCH MED,DEPT PHARMACOL & TOXICOL,LONDON W2 1PG,ENGLAND

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 1992年 / 41卷 / 02期

关键词：

D O I：

10.1016/0026-0495(92)90140-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Although it is now generally regarded that the origin of urinary trimethylamine (TMA) is via the action of intestinal microflora on precursors such as choline, little direct evidence exists. The normal production of urinary TMA was shown to be absent in germ-free mice and greatly reduced in antibiotic-pretreated animals. Cohabitation of germ-free mice with conventional animals restored their ability to excrete TMA. This study invokes a fundamental role for the intestinal microflora in the provision of TMA from precursors within the food. © 1992.

引用

页码：135 / 136

页数：2

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