LIGUSTRAZINE SELECTIVELY BLOCKS ATP-SENSITIVE K+ CHANNELS IN MOUSE PANCREATIC BETA-CELLS

被引：7

作者：

PEERS, C

SMITH, PA

NYE, PCG

机构：

[1] University Laboratory of Physiology, Oxford, OX1 3PT England, Parks Road

来源：

FEBS LETTERS | 1990年 / 261卷 / 01期

基金：

英国惠康基金;

关键词：

ATP-sensitive potassium channel; Ligustrazine; Pancreatic; β; cell; Potassium current;

D O I：

10.1016/0014-5793(90)80622-P

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ligustrazine potently inhibits hypoxic pulmonary vasoconstriction. This effect can be mimicked by the sulphonylurea tolbutamide, a blocker of ATP-sensitive K+ channels. Here we demonstrate that ligustrazine is a specific blocker of ATP-sensitive K+ channels in mouse pancreatic β cells. This suggests that ligustrazine may act in the pulmonary circulation by blocking ATP-sensitive K+ channels. © 1990.

引用

页码：5 / 7

页数：3

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