PAF FORMATION BY HUMAN GASTROINTESTINAL MUCOSA SUBMUCOSA INVITRO - RELEASE BY RICINOLEIC ACID, AND INHIBITION BY 5-AMINOSALICYLIC ACID

被引：10

作者：

CAPASSO, F

TAVARES, IA

BENNETT, A

机构：

[1] KINGS COLL SCH MED & DENT,RAYNE INST,DEPT SURG,123 COLDHARBOUR LANE,LONDON SE5 9NU,ENGLAND

[2] NAPLES UNIV,DEPT EXPTL PHARMACOL,I-80131 NAPLES,ITALY

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1992年 / 44卷 / 09期

基金：

英国惠康基金;

关键词：

D O I：

10.1111/j.2042-7158.1992.tb05518.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Human isolated gastrointestinal mucosa/submucosa incubated with ricinoleic acid (12.5-100-mu-g mL-1) or the calcium ionophore A23187 (10-mu-g mL-1) released platelet-activating factor (PAF) as determined by a scintillation proximity assay after extraction and purification. 5-Aminosalicylic acid (25-100-mu-g mL-1) inhibited PAF release by ricinoleic acid in a concentration-dependent manner, and 50-mu-g mL-1 reduced the effect of A23187. We suggest that PAF may play a role in the laxation and mucosal damage by ricinoleic acid released from castor oil.

引用

页码：771 / 772

页数：2

共 8 条

[1] INCREASED CELL LOSS IN THE HUMAN JEJUNUM INDUCED BY LAXATIVES (RICINOLEIC ACID, DIOCTYL SODIUM SULFOSUCCINATE, MAGNESIUM-SULFATE, BILE-SALTS) [J].