THE EFFECT OF A RANGE OF ALCOHOLS ON THE CONTRACTION OF GUINEA-PIG VENTRICULAR MYOCYTES

被引：3

作者：

CANNINGS, I

HARRISON, S

WHITE, E

BOYETT, M

机构：

[1] Department of Physiology, University of Leeds, Leeds

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY SECTION | 1993年 / 248卷 / 02期

基金：

英国惠康基金;

关键词：

HEART; CARDIAC MYOCYTES; CONTRACTIONS; ALCOHOL;

D O I：

10.1016/0926-6917(93)90046-S

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Previous results have shown that ethanol and some anaesthetics have a negative inotropic effect on the heart. This study was undertaken to investigate the influence of a range on n-alcohols (with chain lengths from 2 to 8) on contractility in guinea-pig ventricular myocytes. The results demonstrate that the negative inotropic action of alcohols increases dramatically as the chain length increases. The concentration required to reduce the magnitude of contraction to 50% of control (IC50) was 274 mM, 26 mM, 1.4 mM and 235 muM for ethanol, butanol, hexanol and octanol, respectively. The relationship between the logarithm of IC50 and chain length was linear for all the alcohols tested (up to a chain length of 8).

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收藏

页码：213 / 216

页数：4

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