PLASMA ADRENOMEDULLIN IN VARIOUS DISEASES AND EXERCISE-INDUCED CHANGE IN ADRENOMEDULLIN IN HEALTHY-SUBJECTS

被引：65

作者：

TANAKA, M ^{[1
]}

KITAIMURA, K ^{[1
]}

ISHIZAKA, Y ^{[1
]}

ISHIYAMA, Y ^{[1
]}

KATO, J ^{[1
]}

KANGAWA, K ^{[1
]}

ETO, T ^{[1
]}

机构：

[1] MIYAZAKI MED COLL,DEPT INTERNAL MED 1,MIYAZAKI 88916,JAPAN

来源：

INTERNAL MEDICINE | 1995年 / 34卷 / 08期

关键词：

HUMAN ADRENOMEDULLIN; HEART DISEASE; RENAL DISEASE; ESSENTIAL HYPERTENSION; PHYSICAL EXERCISE;

D O I：

10.2169/internalmedicine.34.728

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Adrenomedullin is a novel hypotensive peptide recently discovered in human pheochromocytoma. In the present study, we measured the plasma immunoreactive adrenomedullin of healthy subjects and patients with various diseases. Immunoreactive adrenomedullin was found to circulate in blood of the healthy subjects at a considerable concentration (3.3+/-0.3 fmol/ml). Plasma adrenomedullin was significantly increased in the patients with congestive heart failure (5.4+/-0.3 fmol/ml), essential hypertension (5.3+/-0.4 fmol/ml) and renal disease (4.9+/-0.4 fmol/ml). In healthy volunteers physical exercise significantly increased the plasma adrenomedullin concentration. The increase of adrenomedullin was inversely related to systolic blood pressure. These findings indicate that adrenomedullin participates in the circulation control in both physiological and diseased conditions. Although the exact origin of circulating adrenomedullin is still unknown, it is thought to be released rapidly by acute exercise, thereby regulating the cardiovascular system by its vasodilating activity.

引用

页码：728 / 733

页数：6

共 7 条

[1]

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[7]

Sugo S., Minamino N., Kangawa K., Et al., Endothelial cells actively synthesized and secrete adrenomedullin, Biochem Biophys Res Commun, 201, (1994)

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