AIRWAYS RESPONSES TO IPRATROPIUM BROMIDE DO NOT VARY WITH TIME IN ASTHMATIC SUBJECTS - STUDIES OF INTERINDIVIDUAL AND INTRAINDIVIDUAL VARIATION OF BRONCHODILATATION AND PROTECTION AGAINST HISTAMINE-INDUCED BRONCHOCONSTRICTION

Bronchial histamine provocation tests were performed in nine patients with nonallergic asthma on four consecutive days 45 minutes after inhalation of placebo or ipratropium bromide in a dose-response manner (40 μg, 200 μg, and 800 μg). The drugs were administered double-blind, one dose on each day. This procedure was repeated identically after three to nine months to investigate whether the bronchial responses to ipratropium bromide are constant or change with time. Ipratropium bromide induced a significantly better bronchodilatation and protection against histamine-induced bronchoconstriction than placebo with no differences between the three doses. No correlation between bronchodilatation and protection was found. In six asthmatic patients ('responders') ipratropium bromide induced a significant protective effect against histamine-induced bronchoconstriction but no dose-response relationship was found. In three patients none or a very poor protective effect was found at all dose levels ('nonresponders'). The protective effect of ipratropium bromide against histamine-induced bronchoconstriction did not differ between the first and second occasion. Thus, the bronchoprotection differed between different asthmatic subjects but did not vary with time (three to nine months) within the same subject. This finding seems to be of clinical importance since it implicates that the effect of anticholinergic agents on the airways is predictable.