OROTATE COMPLEXES - SYNTHESIS AND CRYSTAL-STRUCTURE OF LITHIUM OROTATE(-I) MONOHYDRATE AND MAGNESIUM BIS[OROTATE(-I)] OCTAHYDRATE

被引：72

作者：

BACH, I ^{[1
]}

KUMBERGER, O ^{[1
]}

SCHMIDBAUR, H ^{[1
]}

机构：

[1] TECH UNIV MUNICH,INST ANORGAN CHEM,LICHTENBERGSTR 4,W-8046 GARCHING,GERMANY

来源：

CHEMISCHE BERICHTE | 1990年 / 123卷 / 12期

关键词：

OROTATE COMPLEXES; SALTS; MAGNESIUM COMPLEXES; LITHIUM COMPLEXES; MAGNESIUM THERAPY;

D O I：

10.1002/cber.19901231207

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Neutralization of orotic acid (OrH2) by lithium or magnesium hydroxide in aqueous medium yields the crystalline metal orotate hydrates Li(OrH).H2O (1) and Mg(OrH)2. (H2O)8 (2). By single-crystal X-ray diffraction studies it has been shown that 1 (space group P1) forms a layer structure, with lithium in a tetrahedral environment of oxygen atoms from three different orotate(-I) anions (one carboxylate and two uracil oxygen atoms) and the water molecule. 2(space group P2(1)/c) has been shown to feature a hexaquo complex of magnesium, the Mg(H2O)62 + cations being associated with two hydrated OrH-ions only through hydrogen bonds. The anions are also engaged in ''base-pairing'' hydrogen bonds between the planar uracil ring systems of different units. The results are relevant for applications of magnesium orotates in magnesium therapy.

引用

页码：2267 / 2271

页数：5

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