A CONTROLLED RELEASE MATRIX USING A MIXTURE OF HYDROPHILIC AND HYDROPHOBIC POLYMERS

被引：10

作者：

ALHMOUD, H ^{[1
]}

EFENTAKIS, M ^{[1
]}

CHOULIS, NH ^{[1
]}

机构：

[1] UNIV ATHENS,SCH PHARM,DEPT PHARMACEUT TECHNOL,104 SOLONOS ST,GR-10680 ATHENS,GREECE

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1991年 / 68卷 / 1-3期

关键词：

CONTROLLED RELEASE; EUDRAGIT RS 100; CARBOXYMETHYL CELLULOSE; PROPRANOLOL HCL;

D O I：

10.1016/0378-5173(91)90155-H

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

A mixture of acrylic resin and carboxymethyl cellulose was used for the preparation of a matrix in an attempt to modify the release rate of propranolol HCI. The dissolution data indicate that it is possible to prepare a dosage form from these polymers capable of delivering the drug at constant rate (zero-order release).

引用

页码：R1 / R3

页数：3

共 5 条

[1]

ALDERMAN D A, 1984, International Journal of Pharmaceutical Technology and Product Manufacture, V5, P1

[2]

ZERO-ORDER RELEASE HYDROPHILIC MATRIX TABLETS OF BETA-ADRENERGIC BLOCKERS [J].

BAVEJA, SK ;

RAO, KVR ;

DEVI, KP .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1987, 39 (1-2) :39-45

[3]

EFENTAKIS M, 1990, IN PRESS ACTA PHARM

[4]

CONTROLLED-RELEASE THEOPHYLLINE TABLET FORMULATIONS CONTAINING ACRYLIC RESINS .1. DISSOLUTION PROPERTIES OF TABLETS [J].

MCGINITY, JW ;

CAMERON, CG ;

CUFF, GW .

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1983, 9 (1-2) :57-68

[5]

RANGARAO KV, 1988, DRUG DEV IND PHARM, V14, P2299

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