HYPERTHERMIA, UNLIKE IONIZING-RADIATION AND CHEMICAL OXIDATIVE STRESS, DOES NOT STIMULATE PROTEOLYSIS IN ERYTHROCYTES

被引：7

作者：

BARTOSZ, G ^{[1
]}

GACZYNSKA, M ^{[1
]}

RETELEWSKA, W ^{[1
]}

GRZELINSKA, E ^{[1
]}

ROSIN, J ^{[1
]}

机构：

[1] INST OCCUPAT MED,DEPT BIOCHEM,PL-90950 LODZ,POLAND

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY | 1990年 / 22卷 / 01期

关键词：

D O I：

10.1016/0020-711X(90)90073-C

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. 1. Oxidative stress by phenazine methosulfate stimulated proteolysis in erythrocytes. 2. 2. Gamma-irradiation of erythrocytes in the range of 50-1000 Gy also resulted in the induction of proteolysis. 3. 3. Though it has been suggested that hyperthermia imposes an oxidative stress on a cell, hyperthermic exposure of erythrocytes (30 min, 39-49°C) did not stimulate proteolysis during subsequent incubation of whole cells or hemolysates. 4. 4. Proteolytic degradation of spectrin was accelerated during incubation of membranes isolated from cells heated above 45°C but this effect seems to be due rather to thermal denaturation of spectrin than to oxidative modification of cellular proteins by hyperthermia. © 1990.

引用

页码：25 / 30

页数：6

共 22 条

[1]

BAILEY JL, 1962, TECHNIQUES PROTEIN C, P272

[2] EFFECT OF HEAT ON THE CIRCULAR-DICHROISM OF SPECTRIN IN HEREDITARY PYROPOIKILOCYTOSIS [J].