SICKNESS AND RECOVERY OF DOGS CHALLENGED WITH A STREET RABIES VIRUS AFTER VACCINATION WITH A VACCINIA VIRUS RECOMBINANT EXPRESSING RABIES VIRUS N-PROTEIN

被引:36
作者
FEKADU, M
SUMNER, JW
SHADDOCK, JH
SANDERLIN, DW
BAER, GM
机构
关键词
D O I
10.1128/JVI.66.5.2601-2604.1992
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Dogs were vaccinated intradermally with vaccinia virus recombinants expressing the rabies virus glycoprotein (G protein) or nucleoprotein (N protein) or a combination of both proteins. The dogs vaccinated with either the G or G plus N proteins developed virus-neutralizing antibody titers, whereas those vaccinated with only the N protein did not. All dogs were then challenged with a lethal dose of a street rabies virus, which killed all control dogs. Dogs vaccinated with the G or G plus N proteins were protected. Five (71%) of seven dogs vaccinated with the N protein sickened, with incubation periods 3 to 7 days shorter than that of the control dogs; however, three (60%) of the five rabid dogs recovered without supportive treatment. Thus, five (71%) of seven vaccinated with the rabies N protein were protected against a street rabies challenge. Our data indicate that rabies virus N protein may be involved in reducing the incubation period in dogs primed with rabies virus N protein and then challenged with a street rabies virus and, of more importance, in subsequent sickness and recovery.
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页码:2601 / 2604
页数:4
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