AN ANTIBODY TO BETA-AMYLOID AND THE AMYLOID PRECURSOR PROTEIN INHIBITS CELL-SUBSTRATUM ADHESION IN MANY MAMMALIAN-CELL TYPES

被引：98

作者：

CHEN, M

YANKNER, BA

机构：

[1] CHILDRENS HOSP MED CTR,DEPT NEUROL,ENDERS 280,300 LONGWOOD AVE,BOSTON,MA 02115

[2] HARVARD UNIV,SCH MED,DEPT NEUROL,BOSTON,MA 02115

来源：

NEUROSCIENCE LETTERS | 1991年 / 125卷 / 02期

关键词：

BETA-AMYLOID; AMYLOID PRECURSOR PROTEIN; ADHESION; ALZHEIMERS DISEASE;

D O I：

10.1016/0304-3940(91)90034-Q

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

An epitope-specific antibody directed against the first 16 amino acids of the beta amyloid protein (anti-BP16) immunoprecipitated the secreted form of the amyloid precursor protein (APP) from the conditioned medium of PC12 cells. This antibody caused neurite retraction in differentiated PC12 cells and inhibited cell-substratum adhesion in many neuronal and non-neuronal cell types. The inhibitory effect of anti-BP16 was abolished by preabsorption of the antibody with BP16 peptide. Antibodies directed against other domains of APP did not inhibit cell adhesion. The secreted form of APP may be important for cell adhesion in many different mammalian cell types.

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页码：223 / 226

页数：4

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