STERIC FIXATION OF BROMOVINYLURACIL - SYNTHESIS OF FURO[2,3-D]PYRIMIDINE NUCLEOSIDES

被引：19

作者：

EGER, K

JALALIAN, M

SCHMIDT, M

机构：

[1] Universität Leipzig, Institut für Pharmazie, Leipzig, D-04103

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1995年 / 32卷 / 01期

关键词：

D O I：

10.1002/jhet.5570320135

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new synthetic procedure for the preparation of 5,6-dihydrofuro[2,3-d]pyrimidin-2(3H)-one (3) and its deoxyriboside 8 is reported. Compound 3 undergoes nucleophilic reactions with various agents to yield 5-substituted uracil derivatives. The dehydro derivative of 3, furo[2,3-d]pyrimidin-2(3H)-one (18) was synthesized by cyclization of BVU 15, which made us develop a reproducible and high yield method for the synthesis of BV(D)U. Starting from 18, the alpha-deoxyriboside 20 and the beta-riboside 22 were prepared.

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页码：211 / 218

页数：8

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