SYNTHESIS AND BIOLOGY OF SUBSTITUTED 3'-PHENYL TAXOL ANALOGS

被引：12

作者：

GEORG, GI ^{[1
]}

CHERUVALLATH, ZS ^{[1
]}

HARRIMAN, GCB ^{[1
]}

HEPPERLE, M ^{[1
]}

PARK, H ^{[1
]}

HIMES, RH ^{[1
]}

机构：

[1] UNIV KANSAS,DEPT BIOCHEM,LAWRENCE,KS 66045

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 19期

关键词：

D O I：

10.1016/0960-894X(94)85035-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of substituted 3'-phenyl taxol analogues, directed by the Topliss Operational Scheme, were synthesized and evaluated for their biological activity. The novel analogues were prepared from baccatin III and N-acyl beta-lactams. Evaluation in the microtubule assembly assay and for cytotoxicity against B16 melanoma cells illustrated a modest influence of aromatic substitution on bioactivity.

引用

页码：2331 / 2336

页数：6

共 35 条

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