GENOTOXIC ACTIVITY OF 1,3-BUTADIENE AND NITROGEN-DIOXIDE AND THEIR PHOTOCHEMICAL-REACTION PRODUCTS IN DROSOPHILA AND IN THE MOUSE BONE-MARROW MICRONUCLEUS ASSAY

被引：20

作者：

VICTORIN, K

BUSK, L

CEDERBERG, H

MAGNUSSON, J

机构：

[1] UNIV STOCKHOLM,WALLENBERG LAB,DEPT GENET & CELLULAR TOXICOL,S-10691 STOCKHOLM,SWEDEN

[2] SWEDISH NATL FOOD ADM,S-75126 UPPSALA,SWEDEN

来源：

MUTATION RESEARCH | 1990年 / 228卷 / 02期

关键词：

Butadiene; Drosophila; Genotoxicity; Micronucleus assay; Nitrogen dioxide; Photochemical products;

D O I：

10.1016/0027-5107(90)90077-H

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The genotoxic activity of a photochemical reaction mixture of 1,3-butadiene and nitrogen dioxide was investigated in vivo in the mouse bone marrow micronucleus assay and the somatic mutation and recombination test in Drosophila (the wing spot test). Butadiene alone was not mutagenic in Drosophila, but induced micronuclei in mice at 10 ppm after 23 h of exposure. Nitrogen dioxide was not genotoxic in either test system. The photochemical reaction products were toxic but probably not mutagenic in Drosophila and not genotoxic in mouse bone marrow. Then in vivo results do not confirm earlier in vitro results that demonstrated a strong direct-acting mutagenic activity of the photochemical products in Salmonella. © 1990.

引用

页码：203 / 209

页数：7

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