NAPROXEN PREVENTION OF HETEROTOPIC OSSIFICATION AFTER HIP-ARTHROPLASTY - A PROSPECTIVE CONTROL STUDY OF 55 PATIENTS

被引：39

作者：

GEBUHR, P ^{[1
]}

SOELBERG, M ^{[1
]}

ORSNES, T ^{[1
]}

WILBEK, H ^{[1
]}

机构：

[1] UNIV COPENHAGEN,HVIDOVRE HOSP,DEPT ORTHOPED,DK-2650 HVIDOVRE,DENMARK

来源：

ACTA ORTHOPAEDICA SCANDINAVICA | 1991年 / 62卷 / 03期

关键词：

D O I：

10.3109/17453679108993597

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

The effect of naproxen on heterotopic ossification after total hip replacement was studied in a randomized, double-blind trial. Twenty-eight patients received 250 mg naproxen thrice daily for 4 weeks postoperatively starting on the morning of the operation while 27 control patients received a placebo. Three months after the operation, 13 patients in the control group had heterotopic ossification compared with 4 patients in the group that received naproxen; and after 1 year, the figures were 15 and 4, respectively (P < 0.01). Three control patients had severe ossifications. We conclude that naproxen given for 4 weeks is sufficient to decrease the incidence of heterotopic ossification after cemented total hip replacement.

引用

页码：226 / 229

页数：4

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