BONE-MARROW CHANGES IN ADJUVANT-INDUCED AND COLLAGEN-INDUCED ARTHRITIS - INTERLEUKIN-1 AND INTERLEUKIN-6 ACTIVITY AND ABNORMAL MYELOPOIESIS

被引：48

作者：

HAYASHIDA, K

OCHI, T

FUJIMOTO, M

OWAKI, H

SHIMAOKA, Y

ONO, K

MATSUMOTO, K

机构：

[1] OSAKA UNIV,SCH MED,DEPT ENVIRONM MED,OSAKA 553,JAPAN

[2] OSAKA UNIV,SCH MED,DEPT PATHOL,OSAKA 553,JAPAN

来源：

ARTHRITIS AND RHEUMATISM | 1992年 / 35卷 / 02期

关键词：

D O I：

10.1002/art.1780350219

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. To investigate the role of bone marrow in arthritis. Methods. Bone marrow changes over time were investigated in rats with adjuvant-induced and collagen-induced arthritis, using bioassay techniques and histologic analysis. Results. In both animal models, bone marrow interleukin-1 and interleukin-6 activity began to rise before the onset of arthritis and increased in relation to the progression of arthritis. Enhanced myelopoiesis in the bone marrow was noted in conjunction with the increased cytokine activity. Conclusion. Bone marrow changes such as those demonstrated in this study may be common to various models of induced arthritis and may have an important role in the pathogenesis of this disease.

引用

页码：241 / 245

页数：5

共 11 条

[1] ELEVATED ACTIVITY OF INTERLEUKIN-1, INTERLEUKIN-2 AND INTERLEUKIN-3 IN THE BONE-MARROW OF COLLAGEN-INDUCED ARTHRITIC RATS [J].