ENTROPY-DRIVEN DNA DENATURATION

被引：424

作者：

DAUXOIS, T

PEYRARD, M

BISHOP, AR

机构：

[1] ECOLE NORMALE SUPER LYON,PHYS LAB,F-69364 LYON 07,FRANCE

[2] LOS ALAMOS NATL LAB,CTR NONLINEAR STUDIES,LOS ALAMOS,NM 87545

[3] LOS ALAMOS NATL LAB,DIV THEORET,LOS ALAMOS,NM 87545

来源：

PHYSICAL REVIEW E | 1993年 / 47卷 / 01期

关键词：

D O I：

10.1103/PhysRevE.47.R44

中图分类号：

O35 [流体力学]; O53 [等离子体物理学];

学科分类号：

070204 ; 080103 ; 080704 ;

摘要：

We present a nonlinear dynamical model for DNA denaturation which includes cooperativity effects through anharmonic nearest-neighbor stacking interactions. Transfer-integral calculations show that this one-dimensional model, without including long-range interactions, exhibits a sharp denaturation reminiscent of a first-order transition at a temperature lower than a similar model with harmonic coupling. Self-consistent phonon calculations point out the essential role of nonlinear effects in the mechanism.

引用

页码：R44 / R47

页数：4

共 20 条

[1] GENERALIZED ONE-DIMENSIONAL ISING-MODEL FOR POLYMER THERMODYNAMICS [J].

AZBEL, MY .

JOURNAL OF CHEMICAL PHYSICS, 1975, 62 (09) :3635-3641

[2] DETERMINATION OF THE SINGLE CHAIN DENSITY OF STATES FOR MEMBRANE SYSTEMS [J].

DAY, J ;

WILLIS, CR .

JOURNAL OF THEORETICAL BIOLOGY, 1981, 88 (04) :693-718

[3] NATURE OF THE OPEN STATE IN LONG POLYNUCLEOTIDE DOUBLE HELICES - POSSIBILITY OF SOLITON EXCITATIONS [J].

ENGLANDER, SW ;

KALLENBACH, NR ;

HEEGER, AJ ;

KRUMHANSL, JA ;

LITWIN, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (12) :7222-7226

[4]

FEYNMAN RP, 1972, STATISTICAL MECHANIC

[5] LARGE-AMPLITUDE NONLINEAR MOTIONS IN PROTEINS [J].

GARCIA, AE .

PHYSICAL REVIEW LETTERS, 1992, 68 (17) :2696-2699

[6] 1ST-ORDER DISPLACIVE STRUCTURAL PHASE-TRANSITIONS STUDIED BY COMPUTER-SIMULATION [J].

KERR, WC ;

HAWTHORNE, AM ;

GOODING, RJ ;

BISHOP, AR ;

KRUMHANSL, JA .

PHYSICAL REVIEW B, 1992, 45 (13) :7036-7053

[7] STRUCTURAL PHASE-TRANSITIONS WITH LITTLE PHONON SOFTENING AND 1ST-ORDER CHARACTER [J].

KRUMHANSL, JA ;

GOODING, RJ .

PHYSICAL REVIEW B, 1989, 39 (05) :3047-3053

[8] CHARACTERIZATION OF BASE-PAIR OPENING IN DEOXYNUCLEOTIDE DUPLEXES USING CATALYZED EXCHANGE OF THE IMINO PROTON [J].

LEROY, JL ;

KOCHOYAN, M ;

HUYNHDINH, T ;

GUERON, M .

JOURNAL OF MOLECULAR BIOLOGY, 1988, 200 (02) :223-238

[9] FINITE-SIZE SCALING STUDY OF A 1ST-ORDER TEMPERATURE-DRIVEN SYMMETRY-BREAKING STRUCTURAL PHASE-TRANSITION [J].

MORRIS, JR ;

GOODING, RJ .

JOURNAL OF STATISTICAL PHYSICS, 1992, 67 (3-4) :471-506

[10] ANALYTIC PREDICTION OF THE EXACT THERMODYNAMICS OF A 1ST-ORDER STRUCTURAL PHASE-TRANSITION - A PRACTICAL 2ND-ORDER SELF-CONSISTENT PHONON THEORY [J].

MORRIS, JR ;

GOODING, RJ .

PHYSICAL REVIEW B, 1992, 46 (14) :8733-8747

← 1 2 →