PENETRATION OF CEFOTETAN INTO SUCTION SKIN BLISTER FLUID AND TISSUE-HOMOGENATES IN PATIENTS UNDERGOING ABDOMINAL-SURGERY

被引：15

作者：

MAZZEI, T ^{[1
]}

TONELLI, F ^{[1
]}

NOVELLI, A ^{[1
]}

FICARI, F ^{[1
]}

MAZZONI, C ^{[1
]}

ANASTASI, A ^{[1
]}

PERITI, P ^{[1
]}

机构：

[1] UNIV FLORENCE,DEPT CLIN PATHOPHYSIOL,FLORENCE,ITALY

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1994年 / 38卷 / 09期

关键词：

D O I：

10.1128/AAC.38.9.2221

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学]; 100705 [微生物与生化药学];

摘要：

The penetration of cefotetan (2-g intravenous bolus) into the suction blister fluid and tissue homogenates of 11 patients was investigated. Mean concentrations in tissue were significantly lower than contemporary suction blister fluid levels. These data show that the determination of beta-lactam concentrations by the tissue homogenate method may seriously underestimate the actual antibiotic levels in extracellular fluid.

引用

页码：2221 / 2223

页数：3

共 17 条

[1]

PULMONARY DISPOSITION OF ANTIMICROBIAL AGENTS - METHODOLOGICAL CONSIDERATIONS [J].