EFFECT OF DIETARY LINOLEIC-ACID ON THE TRYPTOPHAN-NIACIN METABOLISM IN STREPTOZOTOCIN-DIABETIC RATS

被引：16

作者：

EGASHIRA, Y ^{[1
]}

NAKAZAWA, A ^{[1
]}

OHTA, T ^{[1
]}

SHIBATA, K ^{[1
]}

SANADA, H ^{[1
]}

机构：

[1] OSAKA INT UNIV WOMEN,FAC HUMAN SCI,DEPT HUMAN HLTH SCI,MORIGUCHI,OSAKA 570,JAPAN

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-PHYSIOLOGY | 1995年 / 111卷 / 04期

关键词：

AMINOCARBOXYMUCONATESEMIALDEHYDE DECARBOXYLASE; DIABETES; INSULIN; LINOLEIC ACID; NICOTINAMIDE; RAT; TRYPTOPHAN; NIACIN;

D O I：

10.1016/0300-9629(95)00067-H

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To make clear the mechanism of change of tryptophan-niacin metabolism in diabetic rats, we investigated the effect of dietary linoleic acid on the tryptophan-niacin metabolites and the activity of liver, alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD), a key enzyme of tryptophan-niacin metabolism, in streptozotocin diabetic rats, Moreover, we investigated the involvement of linoleic acid in the induction of hepatic ACMSD activity by streptozotocin diabetes, In diabetic rats, the sum of urinary excretion of nicotinamide, N-1-methylnicotinamide (MNA), N-1-methyl-2-pyridone-5-carboxamide (2-Py) and N-1-methyl-4-pyridone-3-carboxamide (4-Py) was higher in the fat free diet group than in the linoleic acid group, that was accompanied by the increase of tryptophan intake and reduction of body weight in the fat free diet group. In diabetic rats, hepatic ACMSD activity was higher in the fat free diet group than in the linoleic acid group. The results indicated that the induction of hepatic ACMSD activity by diabetes was not due to removal of the suppressive effect of the linoleic acid on the enzyme. In the diabetic + insulin group, hepatic ACMSD activity was significantly lower than in the diabetic group.

引用

页码：539 / 545

页数：7

共 16 条

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