CHRYSOSPERMINS, NEW PEPTAIBOL ANTIBIOTICS FROM APIOCREA-CHRYSOSPERMA AP101

被引：49

作者：

DORNBERGER, K ^{[1
]}

IHN, W ^{[1
]}

RITZAU, M ^{[1
]}

GRAFE, U ^{[1
]}

SCHLEGEL, B ^{[1
]}

FLECK, WF ^{[1
]}

METZGER, JW ^{[1
]}

机构：

[1] UNIV TUBINGEN,INST ORGAN CHEM,D-72076 TUBINGEN,GERMANY

来源：

JOURNAL OF ANTIBIOTICS | 1995年 / 48卷 / 09期

关键词：

D O I：

10.7164/antibiotics.48.977

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Four new members of peptaibol antibiotics, designated as chrysospermins A, B, C, and D, were isolated from the mycelium of Apiocrea chrysosperma Ap101 by solvent extraction, silica gel chromatography and preparative recycling HPLC. Their structures as new nonadecapeptides were settled by detailed spectroscopic analysis and chemical degradation experiments. The chrysospermins display antibacterial and antifungal activity, and induce pigment formation by the fungus Phoma destructiva.

引用

页码：977 / 989

页数：13

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