THE VALUE OF PRETREATMENT WITH GONADOTROPIN-RELEASING HORMONE (GNRH) ANALOG IN IVF-ET THERAPY OF SEVERE ENDOMETRIOSIS

被引：36

作者：

DICKER, D ^{[1
]}

GOLDMAN, GA ^{[1
]}

ASHKENAZI, J ^{[1
]}

FELDBERG, D ^{[1
]}

VOLIOVITZ, I ^{[1
]}

GOLDMAN, JA ^{[1
]}

机构：

[1] HASHARON HOSP,GOLDA MEIR MED CTR,SHERMAN FERTIL INST,IL-49372 PETAH TIQWA,ISRAEL

来源：

HUMAN REPRODUCTION | 1990年 / 5卷 / 04期

关键词：

Embryo transfer; Endometriosis; GnRH; GnRH analogue; In-vitro fertilization;

D O I：

10.1093/oxfordjournals.humrep.a137114

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Controversy concerning the optimal treatment of endometriosis and its related infertility still exists. Thirty-one women with moderate and severe endometriosis, who failed to conceive during previous in-vitro fertilization and embryo transfer (IVF-ET) cycles (protocol A), were re-admitted for the procedure following a period of hormonal suppression with a gonadotrophin releasing-hormone (GnRH) agonist (protocol B). Following GnRH analogue treatment, a significantly higher number of oocytes were recovered (P < 0.0006); consequently more embryos were transferred and significantly higher clinical pregnancy rates per cycle (P < 0.0001) were achieved. This difference may be directly related to the beneficial effect of the GnRH analogue on pelvic endometriosis, converting severe cases into mild ones with improved ovarian accessibility and probably oocyte quality. © 1990 Oxford University Press.

引用

页码：418 / 420

页数：3

共 13 条

[1] Chillik C., Acosta A.A., Garcia J.E., Perera S., Van Uem J.F., Rosenwaks Z., Jones H.W., The role of in vitro fertilization in infertile patients with endometriosis, Fend. Steril, 44, pp. 56-69, (1985)
[2] Crosignani P.G., Edwards R.G., Current treatments with LHRH and its analogue, Hum. Reprod, 2, pp. 95-96, (1987)
[3] Dicker D., Vagman I., Abramovitch J., Eckstein N., Goldman J., Ayalon D., GnRH agonist (Buserelin): A new mode of treatment in endometriosis, Hum. Reprod, 2, pp. 20-21, (1987)
[4] Edwards R.G., Steptoe P.C., Current status of in vitro fertilization, Lancet, 2, pp. 1265-1269, (1983)
[5] Feldberg D., Goldman J., Shelef M., Ashkenazi J., Dicker D., Yeshaya A., Comparison of a fixed and dynamic protocol for embryo transfer in an IVF-ET programme, Hum. Reprod, 3, pp. 747-750, (1988)
[6] Matson P.L., Yovich J.L., The treatment of infertility associated with endometriosis by in vitro fertilization, Fertil. Steril, pp. 432-434, (1986)
[7] In vitro fertilization embryo transfer in the United States: 1987 results from the National IVF-ET Registry, Fertil. Steril, 51, (1989)
[8] Oehninger S., Acosta A.A., Kreiner D., Muasher S.J., Jones H.W., Rosenwaks Z., In vitro fertilization and embryo transfer (IVF-ET): An established and successful therapy for endometriosis, J. in Vitro Fertil. Embryo Transfer, 5, pp. 249-256, (1988)
[9] Olive D.L., Haney A.F., Endometriosis associated infertility: A critical review of therapeutic approaches, Obstet. Gynecol. Surv, pp. 538-555, (1986)
[10] Palermo R., Amodeo G., Navot D., Rosenwaks Z., Cittadini E., Concomitant gonadotropin-releasing hormone agonist and menotropin treatment for the synchronized induction of multiple follicles, Fertil. Steril, 49, pp. 290-295, (1988)

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