SERUM SELENIUM CONCENTRATIONS IN RHEUMATOID-ARTHRITIS

被引：40

作者：

ODELL, JR ^{[1
]}

LEMLEYGILLESPIE, S ^{[1
]}

PALMER, WR ^{[1
]}

WEAVER, AL ^{[1
]}

MOORE, GF ^{[1
]}

KLASSEN, LW ^{[1
]}

机构：

[1] VET ADM MED CTR,OMAHA,NE 68105

来源：

ANNALS OF THE RHEUMATIC DISEASES | 1991年 / 50卷 / 06期

关键词：

D O I：

10.1136/ard.50.6.376

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Selenium is a trace element and an essential part of the enzyme glutathione peroxidase, which protects cells from oxidative damage. Selenium has been shown to have anti-proliferative, anti-inflammatory, antiviral, and immune altering effects. Serum selenium concentrations in 101 patients with seropositive rheumatoid arthritis were found to be significantly lower than those in 29 normal, healthy controls (mean (SD) 148 (42) v 160 (25) mu-g/l) and also lower than those in eight patients with fibrositis (148 (42) v 166 (25) mu-g/l). It is speculated that serum selenium concentrations may modulate the effect of viral or other infections in subjects with the appropriate genetic background and in this way enhance the development or progression of rheumatoid arthritis.

引用

页码：376 / 378

页数：3

共 33 条

[1] TRACE-ELEMENTS IN SERUM AND URINE OF PATIENTS WITH RHEUMATOID-ARTHRITIS [J].

AASETH, J ;

MUNTHE, E ;

FORRE, O ;

STEINNES, E .

SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, 1978, 7 (04) :237-240

[2] THE AMERICAN-RHEUMATISM-ASSOCIATION 1987 REVISED CRITERIA FOR THE CLASSIFICATION OF RHEUMATOID-ARTHRITIS [J].

ARNETT, FC ;

EDWORTHY, SM ;

BLOCH, DA ;

MCSHANE, DJ ;

FRIES, JF ;

COOPER, NS ;

HEALEY, LA ;

KAPLAN, SR ;

LIANG, MH ;

LUTHRA, HS ;

MEDSGER, TA ;

MITCHELL, DM ;

NEUSTADT, DH ;

PINALS, RS ;

SCHALLER, JG ;

SHARP, JT ;

WILDER, RL ;

HUNDER, GG .

ARTHRITIS AND RHEUMATISM, 1988, 31 (03) :315-324

[3] SODIUM SELENITE INHIBITION OF THE REPRODUCTION OF SOME ONCOGENIC RNA-VIRUSES [J].

BALANSKY, RM ;

ARGIROVA, RM .

EXPERIENTIA, 1981, 37 (11) :1194-1195

[4]

BLOTCKY AJ, 1973, ANAL CHEM, V45, P1056

[5] STUDIES ON THE RELATIONS OF SELENIUM AND KESHAN DISEASE [J].

CHEN, XS ;

YANG, GQ ;

CHEN, JS ;

CHEN, XC ;

WEN, ZM ;

GE, KY .

BIOLOGICAL TRACE ELEMENT RESEARCH, 1980, 2 (02) :91-107

[6] RELATIONSHIP OF DIETARY SELENIUM CONCENTRATION - CHEMICAL CANCER INDUCTION - TISSUE CONCENTRATION OF SELENIUM IN RATS [J].

HARR, JR ;

EXON, JH ;

WESWIG, PH ;

WHANGER, PD .

CLINICAL TOXICOLOGY, 1973, 6 (03) :487-495

[7]

HELZLSOUER KJ, 1983, SEMIN ONCOL, V10, P305

[8] ADULT AND JUVENILE RHEUMATOID-ARTHRITIS - CURRENT EPIDEMIOLOGIC CONCEPTS [J].

HOCHBERG, MC .

EPIDEMIOLOGIC REVIEWS, 1981, 3 :27-44

[9] AN OCCIDENTAL CASE OF CARDIOMYOPATHY AND SELENIUM DEFICIENCY [J].

JOHNSON, RA ;

BAKER, SS ;

FALLON, JT ;

MAYNARD, EP ;

RUSKIN, JN ;

WEN, Z ;

GE, K ;

COHEN, HJ .

NEW ENGLAND JOURNAL OF MEDICINE, 1981, 304 (20) :1210-1212

[10]

LEBOEUF RA, 1985, CANCER RES, V45, P5496

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