IGA SUBCLASSES IN SPUTUM FROM PATIENTS WITH BRONCHIECTASIS

被引:8
作者
BURNETT, D
HILL, SL
BRADWELL, AR
STOCKLEY, RA
机构
[1] UNIV BIRMINGHAM,DEPT IMMUNOL,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND
[2] UNIV BIRMINGHAM,DEPT MED,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND
关键词
D O I
10.1016/S0954-6111(08)80014-5
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The concentrations of IgA1 and IgA2 were measured in the serum and sputum from 27 clinically stable patients with bronchiectasis. Of the 27 patients, nine were regularly producing mucoid secretions, nine mucopurulent and nine purulent secretions. No significant differences were observed in serum IgA2 concentrations between the patient groups, although IgA1 concentrations were higher in the serum from the patients producing mucopurulent sputum than those producing mucoid or purulent sputum. The sputum concentrations of both IgA1 and IgA2 increased significantly with purulence. Furthermore, there was a significant increase in the proportion of IgA2 as the secretions became more purulent. The sputum concentrations of both IgA subclasses indicated significant local synthesis, with increased production (especially of IgA2) in the presence of inflammation due to infection. © 1990, Baillière Tindall. All rights reserved.
引用
收藏
页码:123 / 127
页数:5
相关论文
共 21 条
[1]   CELLS CONTAINING IGA-SUBCLASSES IN BRONCHI OF SUBJECTS WITH AND WITHOUT CHRONIC OBSTRUCTIVE LUNG-DISEASE [J].
BURNETT, D ;
CROCKER, J ;
STOCKLEY, RA .
JOURNAL OF CLINICAL PATHOLOGY, 1987, 40 (10) :1217-1220
[2]   IMMUNOGLOBULINS IN THE LUNG [J].
BURNETT, D .
THORAX, 1986, 41 (05) :337-344
[3]   INVITRO REGULATION OF IGA SUBCLASS SYNTHESIS .1. DISCORDANCE BETWEEN PLASMA-CELL PRODUCTION AND ANTIBODY SECRETION [J].
CONLEY, ME ;
KOOPMAN, WJ .
JOURNAL OF EXPERIMENTAL MEDICINE, 1982, 156 (06) :1615-1621
[4]  
DELACROIX DL, 1982, IMMUNOLOGY, V47, P383
[5]  
DELACROIX DL, 1985, AM REV RESPIR DIS, V132, P829
[6]   2 ANTIGENICALLY DISTINGUISHABLE SUBCLASSES OF HUMAN A MYELOMA PROTEINS DIFFERING IN THEIR HEAVY CHAINS [J].
FEINSTEIN, D ;
FRANKLIN, EC .
NATURE, 1966, 212 (5069) :1496-+
[7]   PROTEINS OF THE CYSTIC-FIBROSIS RESPIRATORY-TRACT - FRAGMENTED IMMUNOGLOBULIN-G OPSONIC ANTIBODY CAUSING DEFECTIVE OPSONOPHAGOCYTOSIS [J].
FICK, RB ;
NAEGEL, GP ;
SQUIER, SU ;
WOOD, RE ;
GEE, JBL ;
REYNOLDS, HY .
JOURNAL OF CLINICAL INVESTIGATION, 1984, 74 (01) :236-248
[8]   SHORT-TERM RESPONSE OF PATIENTS WITH BRONCHIECTASIS TO TREATMENT WITH AMOXICILLIN GIVEN IN STANDARD OR HIGH-DOSES ORALLY OR BY INHALATION [J].
HILL, SL ;
MORRISON, HM ;
BURNETT, D ;
STOCKLEY, RA .
THORAX, 1986, 41 (07) :559-565
[9]  
KILIAN M, 1980, J IMMUNOL, V124, P2596
[10]   OCCURRENCE AND NATURE OF BACTERIAL IGA PROTEASES [J].
KILIAN, M ;
THOMSEN, B ;
PETERSEN, TE ;
BLEEG, HS .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1983, 409 (JUN) :612-624