AGE AND DISEASE-RELATED CHANGES IN THE MINERAL OF BONE

被引:169
作者
GRYNPAS, M [1 ]
SCHAFFLER [1 ]
CARTER [1 ]
MARTIN [1 ]
RECKER [1 ]
MAROTTI [1 ]
RAISZ [1 ]
BACENA [1 ]
ROSS [1 ]
TURNER [1 ]
机构
[1] MT SINAI HOSP,SAMUEL LUNENFELD RES INST,TORONTO M5G 1X5,ONTARIO,CANADA
关键词
BONE MINERALIZATION; MINERALIZATION PROFILE; AGING; DISEASE; TRACE ELEMENTS;
D O I
10.1007/BF01673403
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Bone mineralization changes with age and disease. The distribution of mineral particles in a given bone (mineralization profile) has been studied using density fractionation as well as microradiography and electron backscattering imaging. The biological determinant of mineralization is the rate of turnover. During rapid growth and periods of high remodeling, mineralization is shifted towards lower mineral density (hypomineralization). During aging and periods of low remodeling, mineralization is shifted towards higher mineral densities (hypermineralization). Chemicals can also influence the mineralization profile of bone. Fluoride induces hypermineralization by stabilizing the apatite lattice and reducing bone mineral solubility, whereas strontium induces hypormineralization by loosening the apatite lattice and increasing bone mineral solubility. Drugs such as bisphosphonates induce hypermineralization by inhibiting resorption and acting as crystal poison. Finally, mineralization can be impaired by defects as in rickets and osteomalacia or made excessive by continuous accretion of mineral without resorption as in osteopetrosis.
引用
收藏
页码:S57 / S64
页数:8
相关论文
共 70 条
  • [1] FACTORS AFFECTING DISTRIBUTION OF ZINC IN HUMAN SKELETON
    AITKEN, JM
    [J]. CALCIFIED TISSUE RESEARCH, 1976, 20 (01): : 23 - 30
  • [2] Albright F, 1948, PARATHYROID GLANDS M, P393
  • [3] AMPRINO R, 1952, ACTA ANAT, V15, P1
  • [4] STRUCTURAL ASPECTS OF AGEING BONE
    ATKINSON, PJ
    [J]. GERONTOLOGIA, 1969, 15 (2-3): : 171 - &
  • [5] BANG S, 1978, EFFECTS FLUORIDE CHE, P56
  • [6] BARBOS MP, 1983, ACTA ANAT, V115, P178
  • [7] STUDIES IN OSTEOPOROSIS - LONG-TERM EFFECT OF OOPHORECTOMY AND OF AMMONIUM-CHLORIDE INGESTION ON BONE OF MATURE RATS
    BARZEL, US
    [J]. ENDOCRINOLOGY, 1975, 96 (05) : 1304 - 1306
  • [8] COMPARATIVE BONE ANALYSIS VIA INFLAMMATION-MEDIATED OSTEOPENIA (IMO) IN THE RAT
    BAUSS, F
    MINNE, HW
    STERZ, H
    WENG, U
    WESCH, H
    ZIEGLER, R
    [J]. CALCIFIED TISSUE INTERNATIONAL, 1985, 37 (05) : 539 - 546
  • [9] INVITRO MODEL OF ALUMINUM-INDUCED OSTEOMALACIA - INHIBITION OF HYDROXYAPATITE FORMATION AND GROWTH
    BLUMENTHAL, NC
    POSNER, AS
    [J]. CALCIFIED TISSUE INTERNATIONAL, 1984, 36 (04) : 439 - 441
  • [10] X-RAY-DIFFRACTION STUDIES OF THE CRYSTALLINITY OF BONE-MINERAL IN NEWLY SYNTHESIZED AND DENSITY FRACTIONATED BONE
    BONAR, LC
    ROUFOSSE, AH
    SABINE, WK
    GRYNPAS, MD
    GLIMCHER, MJ
    [J]. CALCIFIED TISSUE INTERNATIONAL, 1983, 35 (02) : 202 - 209