ALTERATION OF THE EXPRESSION OF HUMAN ESTROGEN-RECEPTOR GENE BY DISTAMYCIN

被引:23
作者
BIANCHI, N
PASSADORE, M
FERIOTTO, G
MISCHIATI, C
GAMBARI, R
PIVA, R
机构
[1] UNIV FERRARA,DIPARTMENTO BIOCHIM & BIOL MOLEC,I-44100 FERRARA,ITALY
[2] UNIV FERRARA,CTR INTERDIPARTIMENTALE BIOTECNOL,I-44100 FERRARA,ITALY
关键词
D O I
10.1016/0960-0760(95)00133-K
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The effects of distamycin on the expression of the estrogen receptor gene were determined in the MCF7 human breast cancer cell line. Estrogen receptor (ER) RNA transcripts were analyzed by Northern blotting and RT-PCR using specific oligonucleotides for the 5' upstream region and for ER cDNA. After ex vivo distamycin treatment of the cells the expression of the canonical ER mRNA isoform of 6.3 kb is strongly inhibited, without appreciable alteration of the accumulation of 5' upstream ER mRNA isoforms. These results suggest that distamycin alters the transcriptional activity of the ER gene causing a change in the ratio between the canonical transcript and other isoforms containing 5' upstream regions.
引用
收藏
页码:211 / 215
页数:5
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