DELAYED FEBRILE RESPONSE IN OLD RATS IS NOT ASSOCIATED WITH AN INABILITY OF HYPOTHALAMUS TO PRODUCE PROSTAGLANDIN E(2)

被引：10

作者：

FRAIFELD, V

ABRAMOVICH, L

KAPLANSKI, J

机构：

[1] Department of Clinical Pharmacology, Corob Center for Medical Sciences, Ben-Gurion University of the Negev, Beer-Sheva, 84105

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 1995年 / 79卷 / 2-3期

关键词：

AGING; BODY TEMPERATURE; HYPOTHALAMIC PROSTAGLANDIN E(2); LIPOPOLYSACCHARIDE (LPS);

D O I：

10.1016/0047-6374(94)01554-Y

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

E. coli lipopolysaccharide (100 mu g per rat, i.p.) induced a twofold increase in hypothalamic prostaglandin E(2) (PGE(2)) production both in young adult (8 months) and old (28-30 months) male Wistar rats. It seems that the ability of the hypothalamus to produce PGE(2) in response to bacterial endotoxin is not affected with aging, and hence delayed febrile response observed in old rats is not related to hypothalamic PGE(2) production.

引用

页码：137 / 140

页数：4

共 9 条

[1] FEVER, TUMOR-NECROSIS-FACTOR, AND INTERLEUKIN-6 IN YOUNG, MATURE, AND AGED FISCHER 344 RATS [J].

FOSTER, KD ;

CONN, CA ;

KLUGER, MJ .

AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 262 (02) :R211-R215

[2] FEVER AND AGING - CENTRAL-NERVOUS-SYSTEM PROSTAGLANDIN-E2 IN RESPONSE TO ENDOTOXIN [J].

GRAHN, D ;

NORMAN, DC ;

YOSHIKAWA, TT .

EXPERIMENTAL GERONTOLOGY, 1987, 22 (04) :249-255

[3]

KAPLANSKI J, 1994, CAN J PHYSL PHARM S1, V72, P283

[4]

KLUGER MJ, 1986, YALE J BIOL MED, V59, P89

[5] INFLUENCE OF SEX AND AGE ON FEBRILE RESPONSES TO PERIPHERAL AND CENTRAL ADMINISTRATION OF PYROGENS IN THE RABBIT [J].

LIPTON, JM ;

TICKNOR, CB .

JOURNAL OF PHYSIOLOGY-LONDON, 1979, 295 (OCT) :263-272

[6] FEVER AND AGING [J].

NORMAN, DC ;

GRAHN, D ;

YOSHIKAWA, TT .

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1985, 33 (12) :859-863

[7] EICOSANOIDS, THERMOGENESIS AND THERMOREGULATION [J].

ROTHWELL, NJ .

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 1992, 46 (01) :1-7

[8] CHARACTERISTICS OF PYROGEN FEVERS ARE ALTERED IN THE AGED RABBIT [J].

RUWE, WD ;

NAYLOR, AM ;

DINARELLO, CA ;

VEALE, WL .

EXPERIMENTAL GERONTOLOGY, 1988, 23 (02) :103-113

[9] THE ASSOCIATION OF ESCHERICHIA-COLI PERITONITIS WITH AN IMPAIRED AND DELAYED FEVER RESPONSE IN SENESCENT RATS [J].

SCARPACE, PJ ;

BORST, SE ;

BENDER, BS .

JOURNALS OF GERONTOLOGY, 1992, 47 (04) :B142-B145

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