INHIBITORY EFFECTS OF CYCLOPIAZONIC ACID ON THE SPIKE AFTER-HYPERPOLARIZATION IN RAT SYMPATHETIC NEURONS

被引：5

作者：

ISHII, Y ^{[1
]}

KAWAI, T ^{[1
]}

WATANABE, M ^{[1
]}

机构：

[1] NAGOYA CITY UNIV,FAC PHARMACEUT SCI,DEPT CHEM PHARMACOL,TANABE DOHRI 3-1,MIZUHO KU,NAGOYA,AICHI 467,JAPAN

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1992年 / 58卷 / 04期

关键词：

D O I：

10.1254/jjp.58.451

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cyclopiazonic acid (CPA), a novel specific inhibitor of Ca2+-ATPase in muscle sarcoplasmic reticulum, shortened the Ca2+-dependent after-hyperpolarization (AHP) following a spike in the rat superior cervical ganglion. This inhibitory effect was reversible and dependent on concentrations between 1 and 5-mu-M. The AHP in the presence of 5-mu-M CPA was not depressed further by ryanodine, nor was it affected by repetitive stimulation. These results suggest that CPA inhibits the intracellular Ca2+ release, probably due to the depletion of Ca2+ stores induced by inhibition of the ATP-dependent Ca2+ pump.

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页码：451 / 456

页数：6

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