DOSE-RESPONSE STUDY WITH HIGH-DOSE INHALED SALMETEROL IN HEALTHY-SUBJECTS

被引：34

作者：

MACONOCHIE, JG ^{[1
]}

FORSTER, JK ^{[1
]}

机构：

[1] GLAXO GRP RES LTD,DEPT MED STAT,GREENFORD UB6 0HE,MIDDX,ENGLAND

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1992年 / 33卷 / 03期

关键词：

SALMETEROL; SALBUTAMOL; PLACEBO; HIGH DOSE; INHALED;

D O I：

10.1111/j.1365-2125.1992.tb04049.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A double-blind, placebo-controlled, cross-over study in 10 healthy male subjects has been carried out to investigate the non-pulmonary effects of single inhaled doses of salmeterol 100-mu-g, 200-mu-g and 400-mu-g and salbutamol 400-mu-g from a metered-dose inhaler. At all doses tested, salmeterol produced statistically significant changes in pulse rate, tremor, blood glucose and plasma potassium concentrations, compared with placebo. All changes were dosed related. A number of dose-related adverse events including tremor, awareness of heart beat and headache were reported after salmeterol administration.

引用

页码：342 / 345

页数：4

共 14 条

[1]

BALL D I, 1987, British Journal of Pharmacology, V92, p746P

[2]

BROWN MJ, 1985, AM J CARDIOL, V56, pD3, DOI 10.1016/0002-9149(85)91107-5

[3] CARDIOVASCULAR AND HYPOKALEMIC EFFECTS OF INHALED SALBUTAMOL, FENOTEROL, AND ISOPRENALINE [J].

CRANE, J ;

BURGESS, C ;

BEASLEY, R .

THORAX, 1989, 44 (02) :136-140

[4] INTRACORONARY INJECTIONS OF SALBUTAMOL DEMONSTRATE THE PRESENCE OF FUNCTIONAL BETA-2-ADRENOCEPTORS IN THE HUMAN-HEART [J].

HALL, JA ;

PETCH, MC ;

BROWN, MJ .

CIRCULATION RESEARCH, 1989, 65 (03) :546-553

[5]

LIPWORTH BJ, 1990, EUR J CLIN PHARMACOL, V38, P203

[6] BETA-ADRENOCEPTOR RESPONSES TO HIGH-DOSES OF INHALED SALBUTAMOL IN PATIENTS WITH BRONCHIAL-ASTHMA [J].

LIPWORTH, BJ ;

CLARK, RA ;

DHILLON, DP ;

BROWN, RA ;

MCDEVITT, DG .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1988, 26 (05) :527-533

[7]

MACONOCHIE JG, 1989, PHARM MED, V2, P321

[8]

MINTON N A, 1991, British Journal of Clinical Pharmacology, V31, p241P

[9] HYPOKALEMIA AND OTHER NON-BRONCHIAL EFFECTS OF INHALED FENOTEROL AND SALBUTAMOL - A PLACEBO-CONTROLLED DOSE-RESPONSE STUDY IN HEALTHY-VOLUNTEERS [J].

SCHEININ, M ;

KOULU, M ;

LAURIKAINEN, E ;

ALLONEN, H .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1987, 24 (05) :645-653

[10]

STRUTHERS AD, 1983, BRIT HEART J, V49, P90

← 1 2 →