SUBSTITUENT EFFECT ON THE ABSOLUTE STEREOCHEMISTRY OF THE ASYMMETRIC REDUCTION OF FLUORINE-CONTAINING BETA-DIKETONES BY BAKERS-YEAST

被引：8

作者：

BUCCIARELLI, M ^{[1
]}

FORNI, A ^{[1
]}

MORETTI, I ^{[1
]}

PRATI, F ^{[1
]}

TORRE, G ^{[1
]}

机构：

[1] UNIV MODENA,DIPARTIMENTO CHIM,VIA CAMPI 183,I-41100 MODENA,ITALY

来源：

BIOCATALYSIS | 1994年 / 9卷 / 1-4期

关键词：

BAKERS YEAST REDUCTION; CHIRAL FLUORINATED BETA-HYDROXYKETONES; ABSOLUTE CONFIGURATION;

D O I：

10.3109/10242429408992130

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fluorine-containing beta-diketones (1a-d) were reduced by free bakers' yeast (FBY) and immobilized baker yeast (IMBY) in water, to give optically-active fluorinated beta-hydroxyketones (2a-d). It was found that the reaction is highly regioselective, and that the stereochemistry of the reduction is controlled by the R substituent.

引用

页码：313 / 320

页数：8

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