THE INFLUENCE OF BREAST SIZE ON LATE RADIATION EFFECTS AND ASSOCIATION WITH RADIOTHERAPY DOSE INHOMOGENEITY

被引：221

作者：

MOODY, AM

MAYLES, WPM

BLISS, JM

AHERN, RP

OWEN, JR

REGAN, J

BROAD, B

YARNOLD, JR

机构：

[1] ROYAL MARSDEN HOSP,DEPT RADIOTHERAPY & ONCOL,SUTTON SM2 5PT,SURREY,ENGLAND

[2] ROYAL MARSDEN HOSP,DEPT PHYS,SUTTON SM2 5PT,SURREY,ENGLAND

[3] INST CANC RES,EPIDEMIOL SECT,SUTTON SM2 5NG,SURREY,ENGLAND

[4] ROYAL MARSDEN HOSP,DEPT COMP,LONDON SW3 6JJ,ENGLAND

[5] CHELTENHAM GEN HOSP,DEPT RADIOTHERAPY & ONCOL,CHELTENHAM GL53 7AN,GLOS,ENGLAND

来源：

RADIOTHERAPY AND ONCOLOGY | 1994年 / 33卷 / 02期

关键词：

BREAST CANCER; LATE RADIATION EFFECT; RADIOTHERAPY DOSE INHOMOGENEITY;

D O I：

10.1016/0167-8140(94)90063-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A prospective assessment of late changes in breast appearance in 559 patients after tumour excision and radiotherapy for early breast cancer noted a strong association with breast size. Only 3/48 (6%) patients with small breasts developed moderate or severe late changes compared with 94/423 (22%) with medium sized breasts and 34/88 (39%) patients with large breasts (p < 0.001), One possibility is that greater radiation changes are related to greater dose inhomogeneity in women with large breasts. To explore this hypothesis, radiation dose distributions were assessed in a separate group of 37 women in whom three-level transverse computer tomographic images of the breast in the treatment position were available. A significant correlation was found between breast size and dose inhomogeneity which may account for the marked changes in breast appearance reported in women with large breasts.

引用

页码：106 / 112

页数：7

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