THE INFLUENCE OF BREAST SIZE ON LATE RADIATION EFFECTS AND ASSOCIATION WITH RADIOTHERAPY DOSE INHOMOGENEITY

被引：217

作者：

MOODY, AM

MAYLES, WPM

BLISS, JM

AHERN, RP

OWEN, JR

REGAN, J

BROAD, B

YARNOLD, JR

机构：

[1] ROYAL MARSDEN HOSP,DEPT RADIOTHERAPY & ONCOL,SUTTON SM2 5PT,SURREY,ENGLAND

[2] ROYAL MARSDEN HOSP,DEPT PHYS,SUTTON SM2 5PT,SURREY,ENGLAND

[3] INST CANC RES,EPIDEMIOL SECT,SUTTON SM2 5NG,SURREY,ENGLAND

[4] ROYAL MARSDEN HOSP,DEPT COMP,LONDON SW3 6JJ,ENGLAND

[5] CHELTENHAM GEN HOSP,DEPT RADIOTHERAPY & ONCOL,CHELTENHAM GL53 7AN,GLOS,ENGLAND

来源：

RADIOTHERAPY AND ONCOLOGY | 1994年 / 33卷 / 02期

关键词：

BREAST CANCER; LATE RADIATION EFFECT; RADIOTHERAPY DOSE INHOMOGENEITY;

D O I：

10.1016/0167-8140(94)90063-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A prospective assessment of late changes in breast appearance in 559 patients after tumour excision and radiotherapy for early breast cancer noted a strong association with breast size. Only 3/48 (6%) patients with small breasts developed moderate or severe late changes compared with 94/423 (22%) with medium sized breasts and 34/88 (39%) patients with large breasts (p < 0.001), One possibility is that greater radiation changes are related to greater dose inhomogeneity in women with large breasts. To explore this hypothesis, radiation dose distributions were assessed in a separate group of 37 women in whom three-level transverse computer tomographic images of the breast in the treatment position were available. A significant correlation was found between breast size and dose inhomogeneity which may account for the marked changes in breast appearance reported in women with large breasts.

引用

页码：106 / 112

页数：7

共 22 条

[1] THE EFFECT OF ADJUVANT CHEMOTHERAPY ON THE COSMETIC RESULTS AFTER PRIMARY RADIATION TREATMENT FOR EARLY STAGE BREAST-CANCER [J].

BEADLE, GF ;

COME, S ;

HENDERSON, IC ;

SILVER, B ;

HELLMAN, S ;

HARRIS, JR .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1984, 10 (11) :2131-2137

[2]

Brierley J D, 1991, Clin Oncol (R Coll Radiol), V3, P6

[3]

BULMAN AS, 1985, EUR J SURG ONCOL, V11, P247

[4] ANALYSIS OF COSMETIC RESULTS AND COMPLICATIONS IN PATIENTS WITH STAGE-I AND STAGE-II BREAST-CANCER TREATED BY BIOPSY AND IRRADIATION [J].

CLARKE, D ;

MARTINEZ, A ;

COX, RS .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1983, 9 (12) :1807-1813

[5] COSMETIC RESULTS FOLLOWING LUMPECTOMY AXILLARY DISSECTION AND RADIOTHERAPY FOR SMALL BREAST CANCERS [J].

DEWAR, JA ;

BENHAMOU, S ;

BENHAMOU, E ;

ARRIAGADA, R ;

PETIT, JY ;

FONTAINE, F ;

SARRAZIN, D .

RADIOTHERAPY AND ONCOLOGY, 1988, 12 (04) :273-280

[6] BREAST IRRADIATION IN THE LATERAL DECUBITUS POSITION - TECHNIQUE OF THE INSTITUT-CURIE [J].

FOURQUET, A ;

CAMPANA, F ;

ROSENWALD, JC ;

VILCOQ, JR .

RADIOTHERAPY AND ONCOLOGY, 1991, 22 (04) :261-265

[7] PRIMARY BREAST IRRADIATION IN LARGE-BREASTED OR HEAVY WOMEN - ANALYSIS OF COSMETIC OUTCOME [J].

GRAY, JR ;

MCCORMICK, B ;

COX, L ;

YAHALOM, J .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1991, 21 (02) :347-354

[8] ASSESSMENT OF SKIN DOSE AND ITS RELATION TO COSMESIS IN THE CONSERVATIVE TREATMENT OF EARLY BREAST-CANCER [J].

HABIBOLLAHI, F ;

MAYLES, HMO ;

MAYLES, WPM ;

WINTER, PJ ;

TONG, D ;

FENTIMAN, IS ;

CHAUDARY, MA ;

HAYWARD, JL .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1988, 14 (02) :291-296

[9] BREAST APPEARANCE AND FUNCTION AFTER BREAST CONSERVING SURGERY AND RADIOTHERAPY [J].

HAMILTON, CS ;

NIELD, JM ;

ADLER, GF ;

CLINGAN, PR .

ACTA ONCOLOGICA, 1990, 29 (03) :291-295

[10] ANALYSIS OF COSMETIC RESULTS FOLLOWING PRIMARY RADIATION-THERAPY FOR STAGE-1 AND STAGE-2 CARCINOMA OF THE BREAST [J].

HARRIS, JR ;

LEVENE, MB ;

SVENSSON, G ;

HELLMAN, S .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1979, 5 (02) :257-261

← 1 2 3 →