REGIOSELECTIVE ANTHRANOYLATION OF DEMETHYLATED ACONITINE - NOVEL ANALOGS OF ACONITINE, INULINE AND METHYLLYCACONITINE

被引：15

作者：

HARDICK, DJ

BLAGBROUGH, IS

WONNACOTT, S

POTTER, BVL

机构：

[1] UNIV BATH,SCH PHARM & PHARMACOL,DEPT MED CHEM,BATH BA2 7AY,AVON,ENGLAND

[2] UNIV BATH,SCH BIOL & BIOCHEM,BATH BA2 7AY,AVON,ENGLAND

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 20期

关键词：

D O I：

10.1016/S0040-4039(00)76911-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The regioselective acylation of 18-O-desmethylaconitine has been achieved with isatoic anhydride to afford the corresponding anthranilate ester, an analogue of inuline. The aniline nitrogen was then incorporated into an S-methylsuccinimide moiety, to afford a novel methyllycaconitine/aconitine hybrid alkaloid.

引用

页码：3371 / 3374

页数：4

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