CADMIUM INDUCTION OF METALLOTHIONEIN SYNTHESIS IN MYTILUS-GALLOPROVINCIALIS

被引：70

作者：

BEBIANNO, MJ ^{[1
]}

LANGSTON, WJ ^{[1
]}

机构：

[1] PLYMOUTH MARINE LAB,CITADEL HILL,PLYMOUTH PL1 2PB,ENGLAND

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1992年 / 103卷 / 01期

关键词：

D O I：

10.1016/0742-8413(92)90231-U

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. The accumulation and subcellular distribution of cadmium and resulting induction of metallothionein has been studied in mussels. Mytilus galloprovincialis, exposed to 400 mug Cd 1-1. 2. Cadmium accumulated by mussels was primarily associated with metallothionein: a maximum four-fold increase in concentrations of the metal-binding protein (3 mg g-1 to 12 mg g-1) was observed after 30 days. 3. Results for M. galloprovincialis confirm the importance of metallothionein in the detoxification of intracellular cadmium and indicate that induction rates are identical to those observed in the closely-related M. edulis. 4. Intercomposition of data between these species may therefore be valid when employing metallothionein assays to determine sub-lethal response to cadmium contamination.

引用

页码：79 / 85

页数：7

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