PHOSPHOINOSITIDE METABOLISM IN AIRWAY SMOOTH-MUSCLE

被引：15

作者：

CHILVERS, ER ^{[1
]}

LYNCH, BJ ^{[1
]}

CHALLISS, RAJ ^{[1
]}

机构：

[1] UNIV LEICESTER,DEPT PHARMACOL & THERAPEUT,LEICESTER LE1 9HN,LEICS,ENGLAND

来源：

PHARMACOLOGY & THERAPEUTICS | 1994年 / 62卷 / 1-2期

基金：

英国惠康基金;

关键词：

AIRWAY SMOOTH MUSCLE; PHARMACOMECHANICAL COUPLING; PHOSPHOINOSITIDE METABOLISM; INOSITOL 1,4,5-TRISPHOSPHATE;

D O I：

10.1016/0163-7258(94)90012-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Agonist-stimulated hydrolysis of phosphatidylinositol 4,5-bisphosphate, which generates inositol 1,4,5-trisphosphate and sn-1,2-diacylglycerol, is thought to be one of the major mechanisms underlying pharmacomechanical coupling in airway smooth muscle. This article is a review of the currently available information on phosphoinositide and inositol 1,4,5-trisphosphate metabolism in this tissue and includes data on inositol 1,4,5-trisphosphate-induced Ca2+ release and the receptor mediating this effect. The final section outlines the potential mechanisms underlying physiological regulation of phosphoinositide metabolism by other second-messenger pathways operative in this tissue.

引用

页码：221 / 245

页数：25

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