INFLUENCE OF FOOD ON THE BIOAVAILABILITY OF METOPROLOL FROM AN OROS SYSTEM - A STUDY IN HEALTHY-VOLUNTEERS

被引：14

作者：

VANDENBERG, G ^{[1
]}

VANSTEVENINCK, F ^{[1
]}

GUBBENSSTIBBE, JM ^{[1
]}

SCHOEMAKER, HC ^{[1
]}

DEBOER, AG ^{[1
]}

COHEN, AF ^{[1
]}

机构：

[1] UNIV HOSP LEIDEN,CTR HUMAN DRUG RES,POB 9600,2300 RC LEIDEN,NETHERLANDS

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1990年 / 39卷 / 03期

关键词：

food intake; metoprolol; oral osmotic drug delivery system (OROS); pharmacokinetics;

D O I：

10.1007/BF00315121

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The influence of food intake on the bioavailability of metoprolol from an OROS system has been investigated. No significant difference was found between OROS administration to fasting subjects or after breakfast in any of the kinetic parameters (AUC, Cmax, tmax, C24 and lag time). Therefore, metoprolol OROS can be administered with breakfast. © 1990 Springer-Verlag.

引用

页码：315 / 316

页数：2

共 4 条

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