HEAT-SHOCK PROTEINS AND CELL-PROLIFERATION

被引：120

作者：

PECHAN, PM

机构：

[1] Max-Planck-Institut für Züchtungsforschung, 5000 Köln 30

来源：

FEBS LETTERS | 1991年 / 280卷 / 01期

关键词：

D O I：

10.1016/0014-5793(91)80190-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Heat shock proteins (Hsps) carry out a number of essential functions in the cell. These functions could be utilized, in a developmentally regulated manner, to affect proteins necessary for cell growth and proliferation. Data showing Hsp involvement in cell proliferation under non-stress conditions are perhaps not altogether surprising in view of the important roles of Hsps in cell metabolism. In a number of cases stress can facilitate cell proliferation in cells which could otherwise not be amenable to this developmental pathway. It is proposed that Hsps could play an essential helper role in initiating this process.

引用

收藏

页码：1 / 4

页数：4

相关论文

共 64 条

[1] THE HEAT-SHOCK RESPONSE IN HELA-CELLS IS ACCOMPANIED BY ELEVATED EXPRESSION OF THE C-FOS PROTOONCOGENE [J].

ANDREWS, GK ;

HARDING, MA ;

CALVET, JP ;

ADAMSON, ED .

MOLECULAR AND CELLULAR BIOLOGY, 1987, 7 (10) :3452-3458

[2] CHARACTERIZATION OF HSP27 AND 3 IMMUNOLOGICALLY RELATED POLYPEPTIDES DURING DROSOPHILA DEVELOPMENT [J].

ARRIGO, AP ;

PAULI, D .

EXPERIMENTAL CELL RESEARCH, 1988, 175 (01) :169-183

[3] HEAT-SHOCK PROTEINS, 1ST MAJOR PRODUCTS OF ZYGOTIC GENE ACTIVITY IN MOUSE EMBRYO [J].

BENSAUDE, O ;

BABINET, C ;

MORANGE, M ;

JACOB, F .

NATURE, 1983, 305 (5932) :331-333

[4] XENOPUS-HSP 70 GENES ARE CONSTITUTIVELY EXPRESSED IN INJECTED OOCYTES [J].

BIENZ, M .

EMBO JOURNAL, 1984, 3 (11) :2477-2483

[5] MECHANISMS OF HEAT-SHOCK GENE ACTIVATION IN HIGHER EUKARYOTES [J].

BIENZ, M ;

PELHAM, HRB .

ADVANCES IN GENETICS INCORPORATING MOLECULAR GENETIC MEDICINE, 1987, 24 :31-72

[6] HEAT-SHOCK PROTEINS AND DEVELOPMENT [J].

BOND, U ;

SCHLESINGER, MJ .

ADVANCES IN GENETICS INCORPORATING MOLECULAR GENETIC MEDICINE, 1987, 24 :1-29

[7]

BRESNICK EH, 1989, J BIOL CHEM, V264, P4992

[8] STEROID-HORMONE REGULATION OF THE ACHLYA-AMBISEXUALIS 85-KILODALTON HEAT-SHOCK PROTEIN, A COMPONENT OF THE ACHLYA STEROID-RECEPTOR COMPLEX [J].

BRUNT, SA ;

RIEHL, R ;

SILVER, JC .

MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (01) :273-281

[9] CHARACTERIZATION, CLONING AND SEQUENCE-ANALYSIS OF THE CDC25 GENE WHICH CONTROLS THE CYCLIC-AMP LEVEL OF SACCHAROMYCES-CEREVISIAE [J].

CAMONIS, JH ;

KALEKINE, M ;

GONDRE, B ;

GARREAU, H ;

BOYMARCOTTE, E ;

JACQUET, M .

EMBO JOURNAL, 1986, 5 (02) :375-380

[10] CELL CYCLE-ASSOCIATED CHANGE IN THE EXPRESSION OF THE PROLIFERATION-SENSITIVE AND HEAT-SHOCK PROTEIN HSX70 (IEF14) - INCREASED SYNTHESIS DURING MITOSIS [J].

CELIS, JE ;

LAURIDSEN, JB ;

BASSE, B .

EXPERIMENTAL CELL RESEARCH, 1988, 177 (01) :176-185

← 1 2 3 4 5 6 7 →