ANTIOXIDANT PROPERTIES OF NATURAL HYDROQUINONES FROM THE MARINE COLONIAL TUNICATE APLIDIUM-CALIFORNICUM

被引：19

作者：

COTELLE, N ^{[1
]}

MOREAU, S ^{[1
]}

BERNIER, JL ^{[1
]}

CATTEAU, JP ^{[1
]}

HENICHART, JP ^{[1
]}

机构：

[1] INSERM,U16,PL VERDUN,F-59045 LILLE,FRANCE

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1991年 / 11卷 / 01期

关键词：

HYDROQUINONES; CHROMENE; SUPEROXIDE ANION; ANTIOXIDANT PROPERTIES; FREE RADICALS;

D O I：

10.1016/0891-5849(91)90188-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antioxidant prenylated hydroquinones and non active chromene or chroman extracted from the marine colonial tunicate Aplidium californicum have been studied in order to throw some light on their biological activity. It has been found that the active compounds inhibit superoxide anion production in rat alveolar macrophages and in the xanthine/xanthine oxidase system. The antioxidant activity may be ascribed rather to a direct reaction of the superoxide anion with the hydroquinones than to an enzymatic inhibition or a membrane signal transfer. A physiological activity close to that of alpha-tocopherol can be considered.

引用

页码：63 / 68

页数：6

共 15 条

[1] Howard, Clarkson, Simple prenylated hydroquinone derivatives from the marine urochordate Aplidium californicum natural anticancer and antimutagenic agents, Tetrahedron Lett., 46, pp. 4449-4452, (1979)
[2] Halliwell, Oxidants and human disease: some new concepts, FASEB J., 1, pp. 358-364, (1987)
[3] Sies, Biochemistry of oxidative stress, Angewandte Chemie International Edition in English, 25, pp. 1058-1071, (1986)
[4] Epstein, Oxygen-derived free radical in postischemic tissue injury, New England Journal of Medicine, 312, pp. 159-163, (1985)
[5] Badwey, Karnovsky, Active oxygen species and the functions of phagocytic leukocytes, Ann. Rev. Biochem., 49, pp. 695-726, (1980)
[6] Halliwell, Guitteridge, Free radicals in biology and medicine, (1985)
[7] McCord, Oxygen-derived free radicals in postischemic tissue injury, New Eng. J. Med., 312, pp. 159-163, (1985)
[8] Greenwald, Superoxide dismutase and catalase as therapeutic agents for human diseases, Free Radic. Biol. Med., 8, pp. 201-209, (1990)
[9] Machlin, Bendich, Free radical tissue damage: protective role of antioxidant nutrients, FASEB J., 6, pp. 441-445, (1987)
[10] Parnham, Graf, Selenoorganic compounds and the therapy of hydroperoxide-linked pathological conditions, Biochem. Pharmacol., 36, pp. 3095-3102, (1987)

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