CARDIOVASCULAR IMPLANT CALCIFICATION - A SURVEY AND UPDATE

被引：58

作者：

LEVY, RJ

SCHOEN, FJ

ANDERSON, HC

HARASAKI, H

KOCH, TH

BROWN, W

LIAN, JB

CUMMING, R

GAVIN, JB

机构：

[1] BRIGHAM & WOMENS HOSP,DEPT PATHOL,BOSTON,MA 02115

[2] HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115

[3] UNIV KANSAS,MED CTR,DEPT PATHOL,KANSAS CITY,KS 66103

[4] CLEVELAND CLIN,DEPT ARTIFICIAL ORGANS,CLEVELAND,OH 44106

[5] UNIV COLORADO,DEPT CHEM,BOULDER,CO 80309

[6] AMER DENT ASSOC,ROCKVILLE,MD

[7] UNIV MASSACHUSETTS,DEPT ANAT & CELL BIOL,WORCESTER,MA 01605

[8] ABIOMED,DANVERS,MA

[9] UNIV AUCKLAND,DEPT EXPTL PATHOL,AUCKLAND,NEW ZEALAND

来源：

BIOMATERIALS | 1991年 / 12卷 / 08期

关键词：

PROSTHESES; CALCIFICATION; POLYMERS;

D O I：

10.1016/0142-9612(91)90017-5

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Calcification of cardiovascular prosthetic implants is a common and important problem. This review provides an update based upon the Conference on Cardiovascular Implant Calcification held as part of the 13th World Congress of the International Society for Heart Research, 1989. A variety of cardiovascular prostheses are affected clinically by calcification, including bioprosthetic heart valves, aortic homografts and trileaflet polymeric valve prostheses. In addition, experimental studies have demonstrated calcification of artificial heart devices in ventricular assist systems in long-term calf studies. The pathophysiology of this disease process is incompletely understood. A common element between the various types of cardiovascular implant calcification is the localization of calcific deposits to devitalized cells and membranous debris. Prevention of cardiovascular implant calcification by either biomaterial modifications or regional drug therapy (controlled release) is being investigated.

引用

页码：707 / 714

页数：8

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