PAECILOQUINONE-A, PAECILOQUINONE-B, PAECILOQUINONE-C, PAECILOQUINONE-D, PAECILOQUINONE-E AND PAECILOQUINONE-F - NEW POTENT INHIBITORS OF PROTEIN-TYROSINE KINASE PRODUCED BY PAECILOMYCES-CARNEUS .2. CHARACTERIZATION AND STRUCTURE DETERMINATION

被引：18

作者：

FREDENHAGEN, A ^{[1
]}

HUG, P ^{[1
]}

SAUTER, H ^{[1
]}

PETER, HH ^{[1
]}

机构：

[1] CIBA GEIGY LTD,DEPT PHYS,RES SERV,CH-4002 BASEL,SWITZERLAND

来源：

JOURNAL OF ANTIBIOTICS | 1995年 / 48卷 / 03期

关键词：

D O I：

10.7164/antibiotics.48.199

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Paeciloquinones A to F and versiconol have been isolated as inhibitors of protein tyrosine kinases from the culture broth of the fungus Paecilomyces carneus P-177. The structures of the new anthraquinones were determined by spectroscopic methods, mainly H-1 NMR and C-13 NMR. The substitution pattern was established by investigation of the respective methylated derivatives.

引用

页码：199 / 204

页数：6

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