DESIGN AND SYNTHESIS OF 6-FLUOROPURINE ACYCLONUCLEOSIDES - POTENTIAL PRODRUGS OF ACYCLOVIR AND GANCICLOVIR

被引：15

作者：

KIM, DK

KIM, HK

CHAE, YB

机构：

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(01)80350-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

6-Fluoropurine acyclonucleosides 6 and 7 have been prepared as potential prodrugs of acyclovir and ganciclovir. It has been found that compounds 6 and 7 are 11.6 and 7.6 times more efficiently metabolized to acyclovir and ganciclovir by adenosine deaminase than the corresponding 6-aminopurine acyclonucleosides 4 and 12, respectively.

引用

收藏

页码：1309 / 1312

页数：4

相关论文

共 17 条

[1]

BAER HP, 1966, MOL PHARMACOL, V2, P67

[2] AMINO-ACID ESTER PRODRUGS OF ACYCLOVIR [J].

BEAUCHAMP, LM ;

ORR, GF ;

DEMIRANDA, P ;

BURNETTE, T ;

KRENITSKY, TA .

ANTIVIRAL CHEMISTRY & CHEMOTHERAPY, 1992, 3 (03) :157-164

[3] PHARMACOKINETICS OF ACYCLOVIR AFTER INTRAVENOUS AND ORAL-ADMINISTRATION [J].

DEMIRANDA, P ;

BLUM, MR .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1983, 12 :29-37

[4] SELECTIVITY OF ACTION OF AN ANTI-HERPETIC AGENT, 9-(2-HYDROXYETHOXYMETHYL)GUANINE [J].

ELION, GB ;

FURMAN, PA ;

FYFE, JA ;

DEMIRANDA, P ;

BEAUCHAMP, L ;

SCHAEFFER, HJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (12) :5716-5720

[5] STIMULATION OF CELLULAR THYMIDINE KINASES BY HUMAN CYTOMEGALOVIRUS [J].

ESTES, JE ;

HUANG, ES .

JOURNAL OF VIROLOGY, 1977, 24 (01) :13-21

[6]

GOOD SS, 1983, J PHARMACOL EXP THER, V227, P644

[7] HUMAN PHARMACOKINETICS AND TOLERANCE OF ORAL GANCICLOVIR [J].

JACOBSON, MA ;

DEMIRANDA, P ;

CEDERBERG, DM ;

BURNETTE, T ;

COBB, E ;

BRODIE, HR ;

MILLS, J .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1987, 31 (08) :1251-1254

[8] 6-DEOXYACYCLOVIR - A XANTHINE OXIDASE-ACTIVATED PRODRUG OF ACYCLOVIR [J].

KRENITSKY, TA ;

HALL, WW ;

DEMIRANDA, P ;

BEAUCHAMP, LM ;

SCHAEFFER, HJ ;

WHITEMAN, PD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (10) :3209-3213

[9] 9-[(1,3-DIHYDROXY-2-PROPOXY)METHYL]GUANINE - A NEW POTENT AND SELECTIVE ANTIHERPES AGENT [J].

MARTIN, JC ;

DVORAK, CA ;

SMEE, DF ;

MATTHEWS, TR ;

VERHEYDEN, JPH .

JOURNAL OF MEDICINAL CHEMISTRY, 1983, 26 (05) :759-761

[10]

MEIJER H, 1984, FEMS MICROBIOL LETT, V25, P283