HEPATITIS-B VIRUS ANTIGEN-SPECIFIC T-CELL ACTIVATION IN PATIENTS WITH ACUTE AND CHRONIC HEPATITIS-B

被引:138
作者
JUNG, MC
SPENGLER, U
SCHRAUT, W
HOFFMANN, R
ZACHOVAL, R
EISENBURG, J
EICHENLAUB, D
RIETHMULLER, G
PAUMGARTNER, G
ZIEGLERHEITBROCK, HWL
WILL, H
PAPE, GR
机构
[1] UNIV MUNICH, KLINIKUM GROSSHADERN, MED KLIN 2, W-8000 MUNICH 70, GERMANY
[2] MAX PLANCK INST BIOCHEM, W-8033 MARTINSRIED, GERMANY
[3] KRANKENHAUS BARMHERZIGEN BRUDER, MUNICH, GERMANY
[4] KRANKENHAUS SCHWABING, MUNICH, GERMANY
关键词
D O I
10.1016/0168-8278(91)90074-L
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Since the hepatitis B virus is noncytopathic, it is generally believed that the individual specific immune response determines the course of infection. The lack of data about hepatitis B virus-specific T-cell reactions in acute infection led us to investigate the specific cellular immune response of infected individuals in terms of proliferation, and gamma-interferon and lymphotoxin production. Our results demonstrate that peripheral blood mononuclear cells (PBMNC) from patients with acute and chronic hepatitis B respond weakly to HBsAg. In contrast, patients with acute hepatitis show a vigorous response to the nucleocapsid antigen (HBcAg) in terms of proliferation and lymphokine production, while only few chronic virus carriers gave a proliferative response. Either of the antigens could activate lymphocytes to produce gamma-interferon and lymphotoxin, cytokines which may modulate antiviral immune response.
引用
收藏
页码:310 / 317
页数:8
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