LITHIUM HYDROXIDE AQUEOUS METHANOL - MILD REAGENT FOR THE HYDROLYSIS OF BILE-ACID METHYL-ESTERS

被引：33

作者：

DAYAL, B

SALEN, G

TOOME, B

TINT, GS

SHEFER, S

PADIA, J

机构：

[1] Department of Medicine, UMDNJ-New Jersey Medical School

[2] Veterans Administration Medical Center, East Orange, Newark

[3] Strong Memorial Hospital, Rochester, NY

来源：

STEROIDS | 1990年 / 55卷 / 05期

关键词：

bile acid methyl esters; hydrolysis; LiOH/Ag; ·; MeOH; steroids;

D O I：

10.1016/0039-128X(90)90021-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An efficient and convenient procedure for the hydrolysis of bile acid methyl esters is described. This is achieved by the addition of aqueous lithium hydroxide in methanol/dioxane (or tetrahydrofuran) at room temperature. Under these conditions, the formates as well as the acetate derivatives were also hydrolyzed, and the desired bile acids were Isolated in 86 to 94% yield. (Steroids: 55:233-237, 1990). © 1990.

引用

页码：233 / 237

页数：5

共 24 条

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