EXPERIMENTAL FUSARIAL HYALOHYPHOMYCOSIS IN A MURINE MODEL

被引:23
作者
LEGRAND, C
ANAISSIE, E
HASHEM, R
NELSON, P
BODEY, GP
RO, J
机构
[1] UNIV TEXAS, MD ANDERSON CANC CTR, DEPT MED SPECIALTIES, INFECT DIS SECT, HOUSTON, TX 77030 USA
[2] UNIV TEXAS, MD ANDERSON CANC CTR, DEPT PATHOL, HOUSTON, TX 77030 USA
[3] PENN STATE UNIV, FUSARIUM RES CTR, UNIVERSITY PK, PA 16802 USA
关键词
D O I
10.1093/infdis/164.5.944
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The pathogenicity of two clinical strains of Fusarium solani was studied in normal and transiently neutropenic outbred CF1 and CD1 male mice. Three inocula (5 x 10(5), 1 x 10(6), and 5 x 10(6) spores/animal) were tested. Groups of 10 mice each were injected with a single intravenous dose of one inoculum. Mortality correlated with the dose of inoculum, as survival was significantly shorter in mice injected with 5 x 10(6) cfu/mouse than in mice that received 1 x 10(6) or 5 x 10(5) cfu/mouse (P < .001). Necrotizing abscesses with acute branching septate hyphae, neutrophil and macrophage infiltration, and hemorrhage were observed. The median survival of neutropenic mice was shorter than that of normal mice (P < .001). Neutropenic mice did not show evidence of an inflammatory cellular reaction and exhibited significantly higher numbers of fungi per gram of infected tissue (P < .001). Intact host defenses in normal mice were able to confine the infection to the kidneys after initial dissemination. In contrast, disseminated infection persisted in most organs in immunosuppressed animals.
引用
收藏
页码:944 / 948
页数:5
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