TROPHIC EFFECT OF ERYTHROPOIETIN AND OTHER HEMATOPOIETIC FACTORS ON CENTRAL CHOLINERGIC NEURONS INVITRO AND INVIVO

被引：231

作者：

KONISHI, Y

CHUI, DH

HIROSE, H

KUNISHITA, T

TABIRA, T

机构：

[1] NCNP, NATL INST NEUROSCI, DIV DEMYELINATING DIS & AGING, TOKYO 187, JAPAN

[2] NITTA GELATIN INC, RES LAB, OSAKA, JAPAN

来源：

BRAIN RESEARCH | 1993年 / 609卷 / 1-2期

基金：

日本科学技术振兴机构;

关键词：

GRANULOCYTE COLONY-STIMULATING FACTOR; MACROPHAGE COLONY-STIMULATING FACTOR; ERYTHROPOIETIN; ERYTHROID DIFFERENTIATION FACTOR; HEMATOPOIETIC FACTOR; NEUROTROPHIC FACTOR; CHOLINERGIC NEURON;

D O I：

10.1016/0006-8993(93)90850-M

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In vitro granulocyte colony-stimulating factor (G-CSF), macrophage colony-stimulating factor (M-CSF), erythropoietin (EPO), and erythroid differentiation factor (EDF) augmented choline acetyltransferase (ChAT) activity in mouse embryonic primary septal neurons and in cholinergic hybridoma cell line, SN6.10.2.2. This is similar to the effects seen with interleukin-3 (IL-3) or granulocyte-macrophage colony-stimulating factor (GM-CSF). Moreover, in vivo GM-CSF and EPO promoted survival of septal cholinergic neurons in adult rats which had undergone fimbria-fornix transections. These results suggest that some of the hematopoietic factors act on cholinergic neurons as 'neurotrophic factors' to influence the differentiation, maintenance and regeneration of these neurons.

引用

页码：29 / 35

页数：7

共 42 条

[1] BRAIN-DERIVED NEUROTROPHIC FACTOR INCREASES SURVIVAL AND DIFFERENTIATED FUNCTIONS OF RAT SEPTAL CHOLINERGIC NEURONS IN CULTURE [J].