GENETIC-ANALYSIS OF HIV-1 ISOLATES FROM BRAZIL REVEALS PRESENCE OF 2 DISTINCT GENETIC SUBTYPES

被引：100

作者：

LOUWAGIE, J

DELWART, EL

MULLINS, JI

MCCUTCHAN, FE

EDDY, G

BURKE, DS

机构：

[1] HENRY M JACKSON FDN,RES LAB,ROCKVILLE,MD 20850

[2] STANFORD UNIV,SCH MED,DEPT IMMUNOL & MICROBIOL,STANFORD,CA 94305

[3] WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307

[4] MIL MED CONSORTIUM APPL RETROVIRAL RES,WASHINGTON,DC 20306

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 1994年 / 10卷 / 05期

关键词：

D O I：

10.1089/aid.1994.10.561

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The spread of the human immunodeficiency virus type 1 (HIV-1) is by now virtually worldwide. An understanding of the genetic, biological, and immunological differences among isolates collected in different geographic locales is crucial for the development of globally effective vaccines. Here we report the genetic characteristics of 21 HIV-1 isolates from Brazil. The isolates were initially characterized using a heteroduplex mobility assay. The majority (17 of 21) were related to North American/European reference isolates of genetic subtype B. Four isolates belonged to a more recently identified genotype, termed subtype F. The subtype F sequences from Brazil are distinguishable in both gag and env from five other genetic subtypes of HIV-1 currently recognized. Like many locales, Brazil harbors more than one HIV-1 subtype.

引用

页码：561 / 567

页数：7

共 24 条

[1]

BURKE DS, 1990, J ACQ IMMUN DEF SYND, V3, P1159

[2] HIV-1, HIV-2, AND HTLV-INFECTION IN HIGH-RISK GROUPS IN BRAZIL [J].

CORTES, E ;

DETELS, R ;

ABOULAFIA, D ;

XI, LL ;

MOUDGIL, T ;

ALAM, M ;

BONECKER, C ;

GONZAGA, A ;

OYAFUSO, L ;

TONDO, M ;

BOITE, C ;

HAMMERSHLAK, N ;

CAPITANI, C ;

SLAMON, DJ ;

HO, DD .

NEW ENGLAND JOURNAL OF MEDICINE, 1989, 320 (15) :953-958

[3] GENETIC-RELATIONSHIPS DETERMINED BY A DNA HETERODUPLEX MOBILITY ASSAY - ANALYSIS OF HIV-1 ENV GENES [J].

DELWART, EL ;

SHPAER, EG ;

LOUWAGIE, J ;

MCCUTCHAN, FE ;

GREZ, M ;

RUBSAMENWAIGMANN, H ;

MULLINS, JI .

SCIENCE, 1993, 262 (5137) :1257-1261

[4]

DUMITRESCU D, 1994, J INFECT DIS, V169, P281

[5]

FELSENSTEIN J, 1985, EVOLUTION, V39, P783, DOI 10.1111/j.1558-5646.1985.tb00420.x

[6]

Felsenstein J, 2005, CLADISTICS, DOI [10.2987/10-6090.1, DOI 10.1111/J.1096-0031.1989.TB00562.X]

[7]

GOODENOW M, 1989, J ACQ IMMUN DEF SYND, V2, P344

[8]

GRANATO C, 1992, J ACQ IMMUN DEF SYND, V5, P531

[9]

HIGGINS DG, 1992, COMPUT APPL BIOSCI, V8, P189

[10] HIV-1 RETROSPECTIVE SEROEPIDEMIOLOGY [J].

ISHAK, R ;

ISHAK, MOG ;

TSIQUAYE, K ;

CARDOSO, DDP .

REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO, 1989, 31 (02) :80-83

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