CHRONIC LYMPHOCYTIC-LEUKEMIA WITH AN INTERFOLLICULAR ARCHITECTURE - AVOIDING DIAGNOSTIC CONFUSION WITH MONOCYTOID B-CELL LYMPHOMA

被引：8

作者：

NGUYEN, DT ^{[1
]}

DIAMOND, LW ^{[1
]}

SCHWONZEN, M ^{[1
]}

BOHLEN, H ^{[1
]}

DIEHL, V ^{[1
]}

机构：

[1] UNIV COLOGNE,DEPT PATHOL,COLOGNE,GERMANY

来源：

LEUKEMIA & LYMPHOMA | 1995年 / 18卷 / 1-2期

关键词：

CHRONIC LYMPHOCYTIC LEUKEMIA; MONOCYTOID B-CELL LYMPHOMA; CLL; DIAGNOSTIC ERRORS;

D O I：

10.3109/10428199509064940

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Certain low grade B-cell lymphoproliferative disorders can be mistaken for each other morphologically, particularly when there is partial lymph node involvement. We encountered two cases of chronic lymphocytic leukemia, in which the interfollicular growth pattern and the pale appearance of the neoplastic proliferation in the lymph nodes led to a misclassification as monocytoid B-cell lymphoma. The correct diagnosis was established, however, when the lymph node morphology was carefully reexamined, with the knowledge of the clinical history, peripheral blood findings, and bone marrow data. The immunophenotype of the neoplastic cells in the peripheral blood (CD5, CD23, weak fluorescence intensity of surface immunoglobulin and CD22) and the lymph node immunohistochemistry (weak L26 staining, strong MT1 positivity) confirmed the diagnosis of chronic lymphocytic leukemia. These two cases demonstrate the necessity of a systematic approach to lymph node morphology and the utility of a multiparameter approach in the diagnosis of lymphoproliferative disorders.

引用

页码：179 / 184

页数：6

共 39 条

[1]

Matutes E., Worner I., Sainati L., de Oliveira M.P., Catovsky D., Advances in the lymphoproliferative disorders. Review of our experience in the study of over 1000 cases, Biologia & Clinica Hematologica, 11, pp. 53-62, (1989)

[2]

Bennett J.M., Catovsky D., Daniel M.T., Flandrin G., Galton D.A.G., Gralnick H.R., Sultan S., The French-American-British (FAB) cooperative group. Proposals for the classification of chronic (mature) B and T lymphoid leukaemias, J. Clin. Pathol, 42, pp. 567-584, (1989)

[3]

Evans H.L., Butler J.J., Youness E.L., Malignant lymphoma, small lymphocytic type: a clinicopathologic study of 84 cases with suggested criteria for intermediate lymphocytic lymphoma, Cancer, 41, pp. 1440-1455, (1978)

[4]

Ben-Ezra J., Burke J.S., Swartz W.G., Brownell M.D., Brynes R.K., Hill L.R., Nathwani B.N., Oken M.M., Wolf B.C., Woodruff R., Rappaport H., Small lymphocytic lymphoma: a clinicopathologic analysis of 268 cases, Blood, 73, pp. 579-587, (1989)

[5]

Ellison D.J., Nathwani B.N., Cho S.Y., Martin S.E., Interfollicular lymphocytic lymphoma: the diagnostic significance of pseudofollicles, Human Pathol, 20, pp. 1108-1118, (1989)

[6]

Nathwani B.N., Diagnostic significance of morphologic patterns in lymph node proliferations, Neoplastic Hematopathology, pp. 407-425, (1992)

[7]

Sheibani K., Sohn C.C., Burke J.S., Winberg C.D., Wu A.M., Rappaport H., Monocytoid B-cell lymphoma: a novel B-cell neoplasm, Am. J. Pathol, 124, pp. 310-318, (1986)

[8]

Sheibani K., Burke J.S., Swartz W.G., Nademanee A., Winberg C.D., Monocytoid B-cell lymphoma. Clinicopathologic study of 21 cases of a unique type of low grade lymphoma, Cancer, 62, pp. 1531-1538, (1988)

[9]

Sheibani K., Monocytoid B-cell lymphoma, Neoplastic Hematopathology, pp. 629-644, (1992)

[10]

Traweek T.S., Sheibani K., Monocytoid B-cell lymphoma. The biologic and clinical implications of peripheral blood involvement, Am. J. Clin. Pathol, 97, pp. 591-598, (1992)

← 1 2 3 4 →