PROTEIN-KINASE-C ACTIVITY IS ALTERED IN DIABETIC RAT HEARTS

被引：46

作者：

XIANG, H ^{[1
]}

MCNEILL, JH ^{[1
]}

机构：

[1] UNIV BRITISH COLUMBIA,FAC PHARMACEUT SCI,DIV PHARMACOL & TOXICOL,VANCOUVER V6T 1Z3,BC,CANADA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 187卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0006-291X(92)91252-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An elevation in diacylglycerol content in the myocardium from diabetic rats has been reported. Since diacylglycerol is known to be an important second messenger in activating protein kinase C, we carried out a study to investigate the status of protein kinase C activity in the hearts of Wistar diabetic rats. Our results showed that protein kinase C activity was significantly increased in the membrane fraction of diabetic hearts compared with controls, and the increased activity was accompanied by a decrease in cytosolic protein kinase C activity in these diabetic hearts. The increase in the membrane-bound protein kinase C activity thus appears to be due to translocation of the enzyme from the cytosolic to the membrane fraction. These results indicate that the development of diabetic cardiomyopathy is accompanied with a high membrane-bound protein kinase C level. © 1992.

引用

页码：703 / 710

页数：8

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